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Micro > Herpesviridae > Flashcards

Herpesviridae Flashcards

0
Q

Genome of herpes?

A

Double stranded

Linear

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1
Q

Describe virion of herpes?

A

Icosahedral

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2
Q

Three subfamilies of herpes?

A

Alpha
Beta
Gamma

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3
Q

Rapid growth?

A

Alpha

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4
Q

Slow growth?

A

Beta (bagal)

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5
Q

Latency in sensory ganglia

A

Alpha

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6
Q

All herpesvirus have identical MORPHOLOGY and cannot be distinguished under what?

A

EM

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7
Q

Latent infection for alpha?

A

Neurons

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8
Q

2 genus of alpha

A

Simplex

Varicello

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9
Q

Official names of all alpha

A

HHV 1-3
HHV 1 - HSV1
HHV 2 - HSV 2
HHV 3 - VZV

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10
Q

Genus for beta

A

Cytomegalo

Roseola

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11
Q

Genus for gamma

A

Lymphocrypto

Rhadino

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12
Q

Common names for beta

A

CMV (HHV5)
HHV6
HHV7

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13
Q

Hsv 1 and 2 genome share?

A

50-70% homology

Cross reactive epitopes with each other and VZV

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14
Q

Only natural host for HSV

A

Man

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15
Q

Most common form of infection results from a KISS given to a child

A

HSV

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16
Q

Generally HSV 1 causes infection where?

A

Above the belt

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17
Q

40% of genital sores are?

A

HSV1

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18
Q

Primary infection or reactivation HSV?

  • short lived viremia
  • spread to the craniospinal ganglia
  • irradiation or psychological stress
A

Primary
Primary
Reactivation

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19
Q

Most common manifestation of 1• herpetic infection

A

Acut gingivostomatitis

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20
Q

What is the manifestation of acute gingivistomatis?

A

Pain and bleeding of gums

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21
Q

Recurrence of oral hSv

A

Herpes labialis

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22
Q

Lesions found in herpes labialis

A

Papules then vesicles

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23
Q

Vesiculoulcerative lesion; prone to 2• bacterial infection

A

Genital herpes

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24
Q

Common conplaint with genital herpes

A

Dysuria

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25
Q

One of the most serious complications of herpes simplex

A

Ensephalitis

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26
Q

2 forms of herpes simplex encephalitis

A

Neonatal

Focal disease

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27
Q

Global involvement; brain is liquified

A

Neonatal

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28
Q

In focal disease what part of brain is usually involed

A

Temporal

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29
Q

Given in all cases of HSE

A

Acyclovir

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30
Q

Baby usually infected perinatally during passage thru birth canal

A

Neonatal herpes simplex

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31
Q

In neonatal herpes simplex, most common organs involved

A

LAB
LIVER
Adrenals
Brain

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32
Q

Only means of prevention for neonatal hsv

A

Cesarian to mothers

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33
Q

3 categories of disease of neonatal herpes simplex

A

Lesions in skin; disseminated ds to organs; enceph

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34
Q

Occurs in immunocompromised and resembles chicken pox

A

Disseminated herpes simplex

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35
Q

Other cutaneous manifestations pf herpes simplex?

A

Zosteriform
Eczema herpeticum
Herpetic whitlow

36
Q

Rare presentation of herpes simplex wherein dermatomal distribution

A

Zosteriform

37
Q

Lesions that typically affect the fingers( dentists and hospital staff)

A

Herpetic whitlow

38
Q

Rapid result but cannot distinguish bet hSV and Vzv

A

EM of vesicle fluid

39
Q

Can distinguish bet HSV and VZV

A

ImmunoF of skin scrapings

40
Q

Definitive diagnostic approach for HSV

A

Virus isolation!!

41
Q

Mgt for hsv that is oral only and more expensive than acyclovir

A

Famcyclovir

Vala”

42
Q

Main target organ of varicella

A

Skin

43
Q

Vzv becomes latent in the?

A

Cerebral or dorsal root ganglia

44
Q

Vzv entry via?

A

Respiratory tract

45
Q

True or false?

Diagnosis of varicella is made on clinical grounds alone

A

True

46
Q

Most common conplication of varicella

A

Bacterial innfection

47
Q

Earliest symptoms of varicella

A

Malaise and fever

48
Q

Order of rash site?

A

Trunk, face, limbs, mouth

49
Q

Also known as shingles

A

Herpes zoster

50
Q

Intensive pain in zoster that may last for months

A

Postherpetic neuralgia

51
Q

Zoster transmitted to the fetus in the first 20weeks (very rare!!)

A

Congenital vzv infection

52
Q

Vzv can cross the placenta on later stages to infect fetus leading to

A

Neonatal varicella

53
Q

Zoster Ig should be given to?

A

Pregnant who had contact with vzv cases;

Infants whose mothers had it 7days before delivery or upto14 days after delivery

54
Q

Vesicular fluid bet the 2 can be differentiated in EM

A

HSV and Pox

55
Q

Antiviral thrapy only given to these vzv patients

A

Gt 50 years!!

56
Q

Beta herpes virus that is Very species and cell type specific

A

Cmv

57
Q

Only known host for cmv

A

Humans

58
Q

Once infected virus remains in the person for life and nay be reactivated from TIME to TIME

A

Cmv

59
Q

Perinatal infections of cmv occurs at

A

Genital secretions or breast milk

60
Q

Postnatal infections of cmv occurs at?

A

Saliva

61
Q

Syndrome of infective mononucleosis

A

Fever
Lymphadenopathy
Splenomegaly

62
Q

Second most common cause of ment handicap, next to trisomy 21

A

Congental CMV infection

63
Q

Candidate vaccine for CMV

A

Towne strain

64
Q

Major target cell of ebv

A

B lymphpcyte

65
Q

Ebv receptor in cells

A

Cr2 or cd21

66
Q

Three classes of ebv antigens

A

Latent phase;

Early; late

67
Q

Ebv: Nonstructural proteins whose synthesis is nlot dependent on viral DNA replication

A

Early

68
Q

Ebv: includes ebna and lmp

A

Latent phase antigens

69
Q

Ebv is transmitted via

A

Saliva( kissing)

70
Q

2 disease association of ebv in aids patients

A

Oral leukoplakia

Chronic interstitial pneumonitis

71
Q

These atypical cells are present in the blood in IM

A

Downey cells

72
Q

Diagnosis of IM?

A

Heterophil antibody test pr

Detn of igM

73
Q

Malaria infection is a cofactor

A

Burkitts lymphoma

74
Q

Gene that is associated w burkitts lymphoma

A

C myc

75
Q

Malignant tumor of the squamous nasopharynx; most common tumor in men;

A

Nasopharyngeal Ca

76
Q

Occurs exclusively in males who had inherited a defective gebe in the X chrom; accts for half the fatal cases of IM

A

Ducan x linked

77
Q

Screen for early lesions of npc and monitoring treatment

A

AntiEBV VCA IgA

78
Q

Vaccine developed for ebv

A

MA antigeb gp 340/220

79
Q

Main target cell for hhv7

A

T cells

80
Q

Genome resembles cmv

A

Hhv6

81
Q

Cell receptor for HHV6

A

CD46

82
Q

HHV6 and 7 transmitted thru

A

Saliva and breast feedingg

83
Q

As early as what age does hhv 6 and 7 occur?

A

4 mos old

84
Q

Reactivation common in transplant px and during pregnancy

A

HHV6

85
Q

Disease associated with HHV 6and 7

A

Roseola infantum ( 6th ds or exanthem subitum)

86
Q

Cause of roseola from hhv 6

A

6B variant

87
Q

Its genome is 75% G + c, highest among all herpesvirus

A

B virus

88
Q

Disease in humans by B virus

A

Acute ascending myelitis

Encephalomyelitis

Micro (24 decks)

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