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Micro > 4-1 Orthomyxo > Flashcards

4-1 Orthomyxo Flashcards

0
Q

Subtypes are dt antigenic variations of surface glycoproteins

A

HA

NA

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1
Q

Antigenically stable

A

Type C

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2
Q

LRTI caused by?

A

Abc
Rsv
Parainfluenza

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3
Q

Proteins of ortho

A

9 sp

1nsp

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4
Q

CAuses highly infectious viral illness

A

Orthomyxo

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5
Q

Found in mosquitoes, ticks, and banded mongoose

A

Thogotovirus

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6
Q

7 segments?

A

C

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7
Q

Enveloped?

A

Yes

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8
Q

For Release of virus

A

Neuraminidase

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9
Q

For Core receptor

A

Nucleoprotein

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10
Q

Protein For attachment

A

Hemaglutinin

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11
Q

For regulation of mrna splicing

A

Ns1 ns2

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12
Q

Antiviral drugs target what?

A

M2 protein

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13
Q

Target of neutralizing antibodies

A

Hemagglutinin

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14
Q

Ha causes antigenic changes of what?

A

Minor drift

Major shift

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15
Q

Describe the receptor for HA

A

Trisaccharide of sialic, gal, glu

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16
Q

Neuraminidase is important in determination of what?

A

Subtypes!

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17
Q

THGSY is?

A

Standard nomenclature

18
Q

Human and animal strains

A

A

19
Q

Human and swine

A

C

20
Q

Ha has ? Subtypes?

A

15

21
Q

Hiw many subtypes of ha and na recovered in humans

A

4ha

2 na

22
Q

H5n1?

A

Chickens to humans

23
Q

Shift or drift?
New subtype
Minor
Pandemic

A

Shift
Drift
Shift

24
Q

Transmission

A

Inhalation

25
Q

Survives what?

A 
Slow drying
Dust
4c
Seawater
-70c
26
Q

Systemic sx?

A

Dt interferon and lymphokines

27
Q

Local sx?

A

Cilia and mucus secreting cells

28
Q

Important for future protection against infection

A

Antibody

29
Q

Important cause of croup in children Under 1yo

A

A

30
Q

Gastric flu. Type?

A

B

31
Q

Afebrile urti. Type?

A

C

32
Q

Croup is associated with what sx?

A

Otitis media

33
Q

Lung complications?

A

PRimary inf pneumonia
Bacterial pneumonia
Cardiac involvment
Neuro (GBS, reyes, enceph)

34
Q

Sequelae that Affects 2-6yo?

A

Reyes

35
Q

Reyes manifestations

A 
hHiME
Hepato
Hypogly
Mental stat
Inclease bloood ammonia
Enceph
36
Q

Immunity important?

A

IgA IgG

Celular immunity

37
Q

Antibodies to this is the only way to be protective

A

Ha and na, others are not

38
Q

T or f? No cross protection to the types?

A

T

39
Q

Samples best Obtained at what time?

A

3 days after onset

40
Q

Detects hemadsorbing virus

A

Hemadsorption

41
Q

Detects virus antigens

A

Hsf elisa

42
Q

M2 ion channel inhibitors

A

Rimantidine

43
Q

Ineffective against b and c

A

A..amantadine

Micro (24 decks)

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