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Micro > 4-3 Paramyxo > Flashcards

4-3 Paramyxo Flashcards

0
Q

Slam is also known as

A

Cd150

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1
Q

Measles H can bind to what cell?

A

Cd46 and cd150

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2
Q

Slam regulates _______ responses

A

TH1 and TH2

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3
Q

Major internal protein

A

Nucleoprotein

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4
Q

Associated with NP

A

L and P ( polymerase phosphoprotein)

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5
Q

Transmembranous envelope glycoprotein

A

F and H

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6
Q

Inside virion envelope

A

Matrix

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7
Q

Part of trabscription complex

A

Phosphoprotein polymerase

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8
Q

Measles Rash is caused by what cells?

A

T cells

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9
Q

Sequelae in cns resulting frkm development of defective mutants

A

Sspe

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10
Q

Persistent infection w/o lysis can occur in what cells?

A

Human brain cells

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11
Q

What happens after inoculation in the respi tract

A

Local replication

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12
Q

Acts as a slow virus and causes sx and cytopath effect in neurons years after

A

Sspe

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13
Q

T cell deficient children have atypical presentation

A

Giant cell pneumonia w/o rash

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14
Q

Interferon a and b activates what?

A

NK cells

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15
Q

What IL is depressed in measles?

A

IL12

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16
Q

Can be administered after exposure

A

Immmunoglobulin

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17
Q

Transmission of measles

A

Large droplets

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18
Q

Measles most infectious at what stage

A

Prodrome

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19
Q

Prodrome starts w?

A

High fever
4Cs
Photophobia

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20
Q

Most commonly seen in the buccal mucosa, other mucous membranes

A

Koplik spots

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21
Q

Clinical consequences of measles

A 
MAPS:
Measles
Atypical
PME
SSPE
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22
Q

Rashes prominent in distal areas

A

Atypical measles

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23
Q

Serious complication of measles accounts for 60% deaths

A

Pneumonia

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24
Q

Occured in people who recrived older inactivated vaccines

A

Atypical

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25
Q

Recommended specimens for measles

A

Respi secretions
Urine
Blood
Brain

26
Q

What Ig is detected greatly at prodrome

A

IgM

27
Q

Current vaccine used

A

Schwart or moraten

28
Q

People who should not receive mmr?

A

Pregnant
Immunosuppresed
Gelatin/myocin

29
Q

Reduces high risk of measle mortality

A

Vit A

30
Q

Mumps vaccine?

A

Jeryl lynn strain

31
Q

Mild coldlike symptoms

A

Para influenza virus

32
Q

Types 1-3 causes?

A

Second only to rsv to cause severe lower rti

33
Q

Type 4 causes?

A

Mild UPPER respi infection

34
Q

Para influenza especially assoc with

A

CROUP

35
Q

Unlike measles parainfluenza rarely cause

A

Viremia

36
Q

CMI in parainfluenza causes what?

A

Both cell damage and protection

37
Q

T or f? Reinfection in parainfluenza

A

True, milder

38
Q

T or f? Parainf induced protective immunity that is long lived

A

False

39
Q

A para influenza in infants most notably cause

A

Croup

40
Q

Subglottal swelling which may close the airway

A

Croup

41
Q

Principal ddx is epiglotitis by Hib

A

Parainfluenza

42
Q

Specimen for parainfluenza

A

Nasal washings and respi secretions

43
Q

To determine specific serotype of parainfluenza

A

HIB test

44
Q

Method of choice to detect parainfluenZa

A

Rt pcr

45
Q

Mumps most closely associated to?

A

Parainf type 2

46
Q

How is the parotid gland infected?

A

Way of stensens duct

Viremia

47
Q

T or f? In mumps, viremia occurs.

A

T

48
Q

Where are the sites of viremia

A 
Testes
Ovary
Pancreas
Thyroid
Etc
49
Q

Transmission of mumps?

A

Direct person to person;

Rspiratory droplets

50
Q

T or f? Swelling of other glands may occur without parotitis

A

T

51
Q

Virus may cause asymptomatic shedding

A

Mumps

52
Q

How to confirm diagnosis of mumps?

A

Serology, 4fold increase in igM

53
Q

Rsv is the Most common cause of

A

Fatal acute respiratory infrction

54
Q

T or F? Maternal antibody protects infant from infection

A

F

55
Q

Necrosis of bronchi which leads to formation of plugs

A

Rsv

56
Q

T or F? Rsv epidemic occur every year

A

True!! Unlike influenza!!

57
Q

Can also be transmitted by fomites

A

RSv

58
Q

Infants w rsv

A

Lrti

59
Q

Modes of control of rsv

A

Immuno globulin;

Aerosol ribavirin

60
Q

Clinical cnsequence of rsv

A

Bronchiolitis/pneumonia;
Febrile rhinitis and pharyngitis;
Common cold

61
Q

Only virus diff to culture

A

RSv

And metapneumo

62
Q

New paramyxo

A

Nipah and hendra

Micro (24 decks)

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