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REPRO II Exam 2 > Prostatic Neoplasia - Fremont-Smith > Flashcards

Prostatic Neoplasia - Fremont-Smith Flashcards

1
Q

condyloma accuminata

A

benign
-STD - HPV type 6 and 11

most often - coronal sulcus and inner prepuce - under foreskin

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2
Q

bowen disease

A

CIS
-variant high risk HPV - 16

red or gray plaque on shaft

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3
Q

bowenoid papulosis

A

CIS
-variant high risk HPV - 16

multple red-tan papules in young adults

-doesnt go to SCC**

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4
Q

erythroplasia of querat

A

CIS
-variant high risk HPV - 16

shiny red soft red plaque on glans and foreskin

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5
Q

high risk HPV

A

incorporates into host DIA

viral E6 oncoprotein inactivates p53 and E7 inactivates pRB (retinoblastoma)

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6
Q

male HPV infection

A

often don’t see anything

acetowhite - look for tiny lesions

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7
Q

remove a lesion

A

not removing a virus**

still HPV on skin surface
-is the immune system that removes virus

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8
Q

condyloma

A

koilocytic change

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9
Q

does not invade to SCC

A

bowenoid papulosis

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10
Q

perakeratosis

A

nuclei in keratin layer - indicate rapid turnover

whiteness and red lesions

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11
Q

CIS

A

need excised

but not bowenoid papulosis - bc does not invade

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12
Q

invasive SCC of penis

A

rare

risk fx - lack of circumcision, HPV 16/18, age 40-70yo, smoking

slow growing painless tumor

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13
Q

prognosis of penile SCC

A

depends on spread to nodes

no inguinal - 66% 5 year
yes inguinal - 27% 5 years

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14
Q

keratin pearl

A

SCC

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15
Q

pearly penile papules

A

variant of normal**

papillary growth around corona of glans

not sex transmission

will go away after time

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16
Q

appendix testes

A

on a stalk

stalk can become torsioned - ischemic/pain

common issue young boys

see dusky blue through scrotal sac

“the blue dot”

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17
Q

tunica albuginea

A

covers seminiferous tubules

18
Q

pyocele, hydrocele, hematocele

A

around testicle

19
Q

early testicular descent

A

mullerian inhibiting substance

20
Q

late testicular descent

A

androgen dependent

21
Q

cryptorchidism

A

improper testicle descent

22
Q

testicle descent

A

two phases:
1 - transabdominal 6 weeks - due to MIS - from sertoli cells

2 - inguinal scrotal - androgen driven - gubernaculum guides testes

23
Q

risk with cryptorchidism

A

testicular ca
trauma
torsion
infertility

24
Q

orchiopexy

A

surgical correction of cryptorchidism

25
Q

B/L cryptorchidism

A

25%
klinefelters
premature birth
fam hx

26
Q

leydig cells

A

in stroma

27
Q

sertoli cells

A

mixed in with germ cells

required for spermatogenesis
-source of MIS - for initial descent phase of testicle

28
Q

intraabdominal testicle

A

needs to be corrected

-remove or bring down to scrotum

29
Q

cryptorchid testis histo

A

leydig hyperplasia
peritubular fibrosis
only sertoli in tubules

30
Q

prune belly syndrome

A

bilateral cryptorchidism

aka eagle-barret syndrome

absence of abdominal muscles**

31
Q

torsion

A

twisting of spermatic cord

2/3 medially**
1/3 laterally

due to dissociation of tunica vaginalis - this keeps it from torsioning

12 hours to save testicle

32
Q

tunica vaginalis

A

hydrocele space

partial envelopes testicle

involved in torsion

33
Q

attachment to tunica vaginalis

A

stops torsion

not completely developed until 1-2 yrs old

34
Q

in utero torsion

A

testicle present in scrotum

  • no pain
  • hard, discoloration of scrotum
  • may be absent

see fibrosis and hemosiderin

35
Q

torsion after birth

A

acute pain

-swelling and color changes to scrotum

36
Q

bell clapper deformity

A

testicle lateral

not up and down orientation

37
Q

testicular torsion diagnosis

A

color doppler blood flow

also nuclear scan - looking for blood flow

38
Q

epididymis

A

bacteria - gonorrhea, chlamydia

old men - e. coli from UTI - reflux of bacteria up vas

need to culture urine**

also TB

39
Q

syphilis

A

testis affected first and may spare epididymis

40
Q

mumps

A

pressure atrophy due to tunica albuginea

-unusual in kids

41
Q

granulomatous orchitis

A

man has vasectomy

  • sperm to surrounding tissue
  • form granuloma

most common - secondary to BCG for transitional cell carcinoma of bladder
-introduce BCG to bladder - granulomatous change - can get into urine to testicle**

REPRO II Exam 2 (21 decks)

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