PlasmaCellNeoplasms

Question 1

Types of plasma cell neoplasm (PCN)

Answer 1

1. MGUS 
2. Plasmacytoma 
3. Plasma cell myeloma (Multiple myeloma)

Question 2

Types of CHL

Answer 2

1. Nodular sclerosis 
2. Mixed cellularity 
3. Lymphocyte rich 
4. Lymphocyte depleted

Question 3

Findings in MGUS

Answer 3

Monoclonal Ig in serum or urine 
M protein < myeloma levels 
no lytic bone lesions

• NO CRAB symptoms/PCM evidence

Question 4

MGUS is a precursor to…?

Answer 4

plasma cell myeloma (mult. myeloma)

Question 5

Pt population of: 


1. MGUS 

2. Plasmacytoma 

3. Plasma cell myeloma (Multiple myeloma)

Answer 5

1. MGUS: >50 yr
   
2. Plasmacytoma: 5 yr old, Male (2/3)
2. Plasma cell myeloma (Multiple myeloma): >50 yrs

Question 6

Types of plasma cytoma

Answer 6

1. plasmacytoma of bone 


2. extraosseousplasmacytoma

Question 7

plasmacytoma of bone findings

Answer 7

local tumor of bone w/ multiple myeloma like cells
no other lesions 

No M protein (like MGUS and PCM)

Question 8

extraosseousplasmacytoma findings

Answer 8

local mass lesions outside of bone/BM w/ 75% in upper resp. tract

Question 9

Plasma cell myeloma findings

Answer 9

CRAB: 
high Ca2+, renal insufficiency, anemia, bone lesion

M protein in serum or urine (mostly IgG) 
Elevated creatinine 
Rouleux on smear

Question 10

Most frequent symptom of Plasma cell myeloma (multiple myeloma)

Answer 10

bone pain (back/extremities),
weakness/tired

Question 11

CHL driven by?

Answer 11

Hodgkin Reed sternberg cells (RS or HRS), 
which are B cell derived

Question 12

Common markers of CHL 
positive for? negative for?

Answer 12

CD15, CD30

Neg: CD19, CD20, CD45

Question 13

Histo of CHL

Answer 13

multilobular nucleus 
eosinophilic inclusions 
large cytoplasms

Question 14

Breakdown % of CHL

Answer 14

1. Nodular sclerosis 
- 50-80% 

2. Mixed cellularity 
- 20-30% 

3. Lymphocyte rich 
- 5 %
   
4. Lymphocyte depleted 
- 1%

Question 15

Target population of: 


1. Nodular sclerosis 

2. Mixed cellularity

Answer 15

1. Nodular sclerosis: 
- young adults, females


2. Mixed cellularity: 
- Kids/elderly

Question 16

EBV predominance in CHL:

1. Nodular sclerosis 

2. Mixed cellularity 

3. Lymphocyte rich 

4. Lymphocyte depleted

Answer 16

1. Nodular sclerosis 
- EBV in 10-25%
   
2. Mixed cellularity 
- EBV in 75% 

2. Lymphocyte rich 
- no EBV
   
4. Lymphocyte depleted 
- EBV + usually

Question 17

Which CHL is found to have broad collagen bands?

Answer 17

Nodular sclerosis

Question 18

Which CHL is found to have nodular growth pattern with residual germinal centers?

Answer 18

Lymphocyte rich