021615 path uterus Flashcards
appearance of functional endometrium in secretory phase
tortuous secretory glands (lots of glands, not much stroma)
dysfunctional uterine bleeding
any bleeding that’s not in usual cycle/period
causes of dysfunctional uterine bleeding
inflam/endometritis/pelvic inflam dis (retained tissue after conception or miscarriage, acute endometritis from gonrrhea or chlamydia)
polyps
adenomyosis
leiomyomas
premalignant (hyperplasia)
malignant
endometrial polyp
benign biphasic (gland and stroma) neoplastic growth
endometriosis
endometrial glands and stroma with/wo hemosiderin outside of the uterus
discharge of blood cylically leads to reactive changes, fibrosis, and adhesions
tx for endometriosis
cox-2 inhibitors and aromatase inhibitors
adenomyosis
growth of endometrium in myometrium
can cause infertility and bleeding
gross appearnace of adenomyosis
enlarged, nodular myometrium with cysts
endometrial hyperplasia histology
glands to stroma ratio is over 1/1
abnormal glandular architecture (glands are not round tubules as they are in the normal proliferative phase)
endometrial hyperplasia can be due to
prolonged/excess estrogen:
- obesity
- anovulation
- estrogen producing tumors
hyperplasia vs adenocarcinoma
adenocarcinoma only has glands
does endometrial hyperplasia progress to adenomcarcinoma?
yes, it can (the risk is higher with atypia)
types of endometrial adenocarcinoma
type I (estrogen dependent) type II (in atrophic background, indepen of endometrial hyperplasi)
which type of endometrial adenocarcinoma occurs in older women?
type II (avg 70 yrs)–more aggressive than type I
leiomyoma
fibroid
benign
usually asymptomatic and multiple
