0219 - Pathology of the liver

Question 1

What are the pathological changes associated with liver disease?

Answer 1

Generally similar changes regardless of the insult.
Hepatocyte swelling (hydropic change) - defects in membrane/mitochondrial function
Steatosis (fatty change) - accumulation of fat and TAGs in hepatocytes

Question 2

Identify three ways that liver cell death can manifest histologically.

Answer 2

Lytic - Cell swelling
Coagulative necrosis - dark red staining cells
Apoptosis - single cell death

Question 3

How does the liver respond to ongoing injury (histologically)

Answer 3

Hepatocyte proliferation (replace dead cells)
Hepatocyte hypertrophy (englarement of organelles)
Bile ductular proliferation (loss of integrity of bile passages)

Question 4

What are the three subtypes of liver disease?

Answer 4

Hepatic parenchymal disease
Hepatobiliary disorders
Hepatic vascular disorder.