Nucleotide Metabolism

Question 1

Von Gierke’s disease

Answer 1

deficiency in glucose 6-phosphatase activity

Question 2

Regulation of purine biosynthetic pathway

Answer 2

first two steps
end product inhibition and feed forward regulation
cross regulation from IMP to AMP and GMP

Question 3

Adenosine deaminase cycle

Answer 3

replenishes fumarate and TCA intermediates

Question 4

Gout

Answer 4

excess uric acid, blocked by allopurinol (analog of hypoxanthine)

Question 5

Ingested nucleotide location when it’s not in DNA

Answer 5

ends up as uric acid

Question 6

Key precursors

Answer 6

glycine, glutamine, aspartate, folate, PRPP