Immunology 1.3

Question 1

TLR signaling

Answer 1

recognize PAMPS, specific.
they then recruit adapter proteins
recruit protein kinases
activate transcription

Question 2

E-selectin

Answer 2

involved in inflammation, specific to endotelium

Question 3

macrophage activation via LPS

Answer 3

recognized by LBP, MD2, CD14. deliver to TLR complex

TIR domain delivers to MyD88*

Question 4

NFkB signaling

Answer 4

activates pro inflammatory genes and T cells
most important!!!

causes fever through cytokines.

Question 5

TLR4 deficiency

Answer 5

more susceptible to G- bacterial infections

Question 6

NK cells

Answer 6

turned off by inhibitory receptors.

Ig like receptors-

lectin-like receptors- bind carbs

activate macrophages!

Question 7

MHC-1

Answer 7

almost all over. LHA is more specific to humans, better name.

when cell is infected, MIC-ligand receptor overrides positive signal and it kills the cell.

NKC can be activated with decrease of LHA

Question 8

IFN-y

Answer 8

major interferon of NK cells

Question 9

TNF

Answer 9

key mediator of inflammation, control infections.

Question 10

Il-1

Answer 10

discovered as pyrogen, causes fever.

Question 11

chemokines

Answer 11

responsible for tissue influx

recruit cells to specific sites

Question 12

type 1 interferrons

Answer 12

alpha and beta. resistance to viral infection

Question 13

type 2 interferrons

Answer 13

gamma- activate macrophages, major prod of NK cells and T cells.****

Question 14

IL-10, TGF-b

Answer 14

control of inflamation

Question 15

IL-15

Answer 15

proliferation of NK cells

Question 16

gamma chain

Answer 16

lymphocyte development

if you lack this you can’t respond to any of these cytokines

Question 17

IL-2

Answer 17

t cell development

Question 18

IL 4 and IL 5

Answer 18

B-cell development, anti inflamatory

Question 19

IL-6

Answer 19

Pro inflamatory just like GP130

induces acute-phase protein prod by hepatocytes

Question 20

Janus kinase

Answer 20

two faced kinase. used for cytokine signaling

Question 21

STAT

Answer 21

signal transducer and activator of transcription used for cytokine signaling.

Question 22

CXCL8

Answer 22

chemotactic factor recruits neutrophils and basos to site of infection

Question 23

TNF-a

Answer 23

useful at low doses, toxic at high dose
can cause septic shock

fever in brain, vascular collapse

Question 24

IL-12

Answer 24

Activates NK cells.

Question 25

macrophage cytokines

Answer 25

key to innate responses

Question 26

the Herxheimer reaction

Answer 26

occurs when large quantities of endotoxins are relied as bacteria die during antibiotic treatment.

leads to septic shock.

Question 27

cytokine cell activation

Answer 27

bind to receptors and promote nuclear translocation of trans factors such as STAT

Question 28

G-protein coupled receptor with chemokines

Answer 28

look up

Question 29

4 classses of chemokines

Answer 29

CC
CXC- most important because of PMN recruitment
C
CX3C

Question 30

margination

Answer 30

neutrophil recruitment and diapedesis

started by selectin