Inflamation 2

Question 1

white cell casts

Answer 1

nephritis sign. comes out of tubule

Question 2

histiocytes

Answer 2

AKA macrophages

come from monocytes

Question 3

Giant cells

Answer 3

conglomerations of macrophages

Question 4

asbestos

Answer 4

long and needle shaped.

Hemosiderin- iron bearing protein

causes inefective macro response— induce fibrosis.

Question 5

Lymphocytes

Answer 5

..

Question 6

plasma cells

Answer 6

clock faced, eccentric

Question 7

eosinophil

Answer 7

responds to IgE, uses MBP, responds to parasites.

Question 8

Basophil

Answer 8

least common

contain blue granules

IgE coated

Question 9

Asthma

Answer 9

eosinophils^^^^

Question 10

syphilis

Answer 10

spirochetes

skin lesions

Question 11

TNF-a

Answer 11

made by macros, mast, others
activates many cells
prolonged systemic TNF-a causes cachexia

Question 12

IL-1b

Answer 12

made by macros
activates Bcells, CD4 Tcells, endothelial cells
causes fever

Question 13

Interferon gamme

Answer 13

made by lymphos
activates macros
helpful in viral infections

Question 14

arachidonic acid metabolites

Answer 14

crucial inflamatory mediators
cyclooxygenase pathway***- NSAIDS

5-lipooxygenase pathway- leukotrienes

Question 15

cyclooxygenase pathway

Answer 15

NSAIDS and glucocorticoids.

Question 16

gout

Answer 16

chalk like crap in toes, urate crystals.

Question 17

Ki-67

Answer 17

proliferation stain, all proliferation

Question 18

types of collagen

Answer 18

1. most abundant
2. cartilage
3. soft tissue, early wound healing.
4. basement membranes
5. anchoring fibrils to epidermis.

Question 19

steps in tissue healing

Answer 19

inflammatory response
clot forms
fibroblasts, endo cells, and pericytes migrate into clot and for granulation.
granulation tissue matures, forming scar.
scar matures, collagen remodeling

Question 20

primary intention

Answer 20

.

Question 21

secondary intention

Answer 21

.

Question 22

skin healing

Answer 22

mixed inflammatory infiltrate with macros, lymphos, polys.

edema, new vessels, fibros

Question 23

problems in tissue repair

Answer 23

slow, ~10% in one week
only get up to 75% after months

too much scarring, keloid, desmoids

too little, poor perfusion, steriods, diabetes.
wound dehiscence, cardiac rupture after infarct.

Question 24

dehiscence

Answer 24

wound that splits back open.