tRNA/Translation

Question 1

Aminoacyl-tRNA Synthetase

Answer 1

Uses ATP to activate/charge tRNA by adding the correct AA to the 3’ end

Question 2

Site of Peptide Bond Formation

Answer 2

Growing polypep moved by rRNA (ribozyme) from P site onto AA in A site (except for the initiator methionine in P site)

Question 3

Protein Synth Initiation

Answer 3

GTP hydrolysis allows binding of 40/60S subs (or 30/50)

Question 4

5 Antibioitics that Act on 50S (including 2 that act on 23S)

Answer 4

Chloramphenicol
Clindamycin
Streptogramins
Macrolides and Linezolid at 23S

Question 5

2 Antibiotics that Act on 50S

Answer 5

Aminoglycosides

Tetracyclines