RAT #24 - Cell Cycle Regulation

Question 1

CELL CYCLE REGULATION

Which of the following is NOT a Mechanism for Regulation of the Cell Cycle ?

(a) . Proteolysis of Cyclin Proteins
(b) . Protein Phosphorylation
(c) . Proteolysis of cdk/cdc Protein Kinases
(d) . Ubiquitinylation of Proteins
(e) . Synthesis of Cyclin Proteins

Answer 1

(c). Proteolysis of cdk/cdc Protein Kinases

Question 2

CELL CYCLE REGULATION

WHAT Cyclin(s) are required to Pass the G1 Checkpoint in Animal Cells ?

(a) . Cyclin D
(b) . Cyclin B
(c) . Cyclin A
(d) . Cyclin E

Answer 2

INCORRECT

(d).

Question 3

CELL CYCLE REGULATION

The Cell Cycle Checkpoints in G1 and G2, which are similar, Detect ?

a. Levels of Chk1/2
b. Levels of p53
c. Levels of Cyclin D
d. Damaged DNA
e. Chromosome Misalignment

Answer 3

(d). Damaged DNA

Question 4

CELL CYCLE REGULATION

The G1 checkpoint in Mammalian cells that ASSESSES Extracellular Signals is called ?

(a) . the G1/S boundary
(b) . START
(c) . the Restriction Point
(d) . the Decision Point

Answer 4

(c). the Restriction Point

Question 5

CELL CYCLE REGULATION

Cells are restricted to 1 round of DNA Replication per Cell Cycle due to a Groups of Proteins that Bind to the ORI (origin of replication).

What are these Proteins called ?

(a) . MCM proteins
(b) . Cyclins
(c) . Histone proteins
(d) . ATM proteins
(e) . AKT proteins

Answer 5

(a). MCM proteins

Question 6

CELL CYCLE REGULATION

MPF is ?

(a) . a Monomeric Protein Kinase
(b) . a Dimer of cdc2 + Cyclin D
(c) . a Dimer of TWO cdc2 molecules
(d) . a Dimer of cdc2 + Cyclin B
(e) . a Dimer of cdc2 + Cyclin A

Answer 6

(d). a Dimer of cdc2 + Cyclin B

Question 7

CELL CYCLE REGULATION

MPF is a General Regulator for the Transition from ?

(a) . G0 ⟶ G1
(b) . G1 ⟶ G0
(c) . M ⟶ G1
(d) . S ⟶ G2
(e) . G2 ⟶ M

Answer 7

(e). G2 ⟶ M

Question 8

CELL CYCLE REGULATION

Which Component of MPF is Constitutively Expressed (never degraded) ?

(a) . cdc 2
(b) . Cyclin D
(c) . Cyclin A
(d) . cdc25
(e) . Cyclin A

Answer 8

INCORRECT (b).

Question 9

CELL CYCLE REGULATION

MPF ultimately MEDIATES its Own Destruction.

What Target does it Phosphorylate to CAUSE its own Degradation?

(a) . Histone H1
(b) . Anaphase Promoting Factor
(c) . Cyclin B
(d) . Lamins
(e) . Condensins

Answer 9

INCORRECT (c).

Question 10

CELL CYCLE REGULATION

What Target of MPF is Phosphorylated LEADING TO Condensation of Chromatin?

(a) . Cyclin B
(b) . Condensins
(c) . Nuclear Lamins
(d) . Anaphase Promoting Factor
(e) . Histone H1

Answer 10

(b). Condensins