RAT #10 - Transcriptional Regulation - NON-DNA dependent

Question 1

Which of following is NOT a Chemical Modification that IMPACTS Transcription?

a. Hydroxylation
b. Methylation
c. Acetylation
d. Phosphorylation

Answer 1

a. Hydroxylation

Question 2

{True / False}

Chromatin Rearrangement modifies the Histone - DNA structure so Translation can occur.

Answer 2

TRUE

Question 3

Apparently, our Muscle cells are different from our Nerve cells mainly because:

a. they contain different genes
b. they express different genes
c. they have different genetic codes
d. they have different chromosomes

Answer 3

b. they Express different Genes

Question 4

Histone Acetyl-transferases ADD Acetyl groups to Histones making them More NEGATIVE.

What Affect would this have on the DNA association w/ Histones?

a. the DNA would lift away from the Histones (would be repelled)
b. the DNA would bind more tightly to the Histones (would be attracted)
c. this would have NO affect on DNA association w/ Histones
d. the DNA would associate w/ 12 rather than 8 core Histone molecules

Answer 4

a. the DNA would lift away from Histones (would be repelled)

Question 5

Nucleosomes INHIBIT?

a. Assembly of Transcription
b. RNA Polymerases
c. Activators
d. Translation

Answer 5

b. RNA Polymerases

Question 6

{True / False}

miRNAs REGULATE Transcription by Promoting Degradation of its corresponding mRNA.

Answer 6

TRUE

Question 7

ACTIVELY Transcribed Genes are found in what Type of Chromatin?

a. Strenuus Chromatin
b. Heterochromatin
c. Faux Chromatin
d. Euchromatin

Answer 7

d. Euchromatin

Question 8

{True / False}

Chromatin where Histones are DEACETYLATED is Transcriptionally INACTIVE.

Answer 8

TRUE

Question 9

How does Methylation of Histones AFFECT Transcription?

a. Changing the charge of Histones to Negative
b. Promoting the Interaction of Other blocking Transcription factors to prevent Transcription
c. recruiting TFIID to Transcription Promoters
d. loosening the DNA interaction with DNA allowing access of transcription factors to the DNA

Answer 9

b. Promoting the Interaction of Other Blocking Transcription factors to PREVENT Transcription

Question 10

How does RNA-induced Transcriptional Silencing Complexes INHIBIT Transcription?

a. Causing Degradation of mRNA
b. Promoting Heterochromatin formation
* c. Promoting Phosphorylation of the Histone Tails ultimately Blocking Transcription*
d. by Recruiting RISC

Answer 10

INCORRECT

c. Promoting Phosphorylation of the Histone Tails ultimately Blocking Transcription