Drugs that interfere with electron transport chain

Question 1

Who are the electron transport inhibitors?

Answer 1

Rotenone
cyanide
antimycin A
CO

Question 2

Who are the ATP synthase inhibitors

Answer 2

Oligomycin

Question 3

Who are the uncoupling agents

Answer 3

2,4 Dinitrophenol (2,4 DNP)
Aspirin
Thermogenin (brown fat)

Question 4

what is the mechanism of the electron transport inhibitors?

Answer 4

directly inhibit electron transport causing a decrease in proton gradient and blocking ATP synthesis

Question 5

What is the mechanism of the ATP synthase inhibitors

Answer 5

Directly inhibit mitochondrial ATP synthase, causing an increase proton gradient. No ATP is produced because electron transport stops.

Question 6

What is the mechanism behind uncoupling agents

Answer 6

increase permeability of the membrane causing a decrease in the proton gradient and increase in O2 consumption.

ATP synthesis stops
Electron transport continues

Produces HEAT

Question 7

Where does Rotenone inhibit?

Answer 7

Complex 1 : NADH reductase

rotenone is an insecticide/ fish poison

Question 8

Amytal?

Answer 8

Complex 1: NADH reductase

Question 9

MMP?

Answer 9

Complex 1: NADH reductase

Recall that it can cause Parkinsonism like features

Question 10

Antimycin A blocks who?

Answer 10

Complex III: Cytochrome b+ c1

Question 11

Cyanide (CN-) blocks?

Answer 11

Complex 4: Cytochrome a+ a3

Question 12

CO blocks who in the electron transport chain?

Answer 12

Complex 4: Cytochrome a+ a3

Question 13

H2S and N3- block who in the electron transport chain

Answer 13

Complex 4: Cytochrome a+ a3

Question 14

What is the treatment for lung abscesses?

Answer 14

Clindamycin