4

Question 1

Respiratory virus..

Answer 1

Myxovirus/infl
Paramyxovi/parainfl, RSV
Coronavirus
Rhino/picornavirus
Adenovirus
Rheovirus

Question 2

Penyebab tersering common cold

Answer 2

Rhinovirus

Question 3

Transmisi rhinovirus

Answer 3

Inhalasi, kontak tangan

Question 4

Reseptor rhinovirus

Answer 4

CD 54

Question 5

Penyebab kedua tersering common cold

Answer 5

Coronavirus

Question 6

Spesimen coronavirus

Answer 6

Swab nasofaring, BAL, body fluid

Question 7

Karakteristik SARS

Answer 7

HGF, pernapasan berat, riwayat ke daerah endemis

Question 8

Sifat Coronavirus

Answer 8

RNA enveloped, sitoplasmic replication

Question 9

Sifat Adenovirus

Answer 9

ds DNA, non-enveloped, nucleus replication

Question 10

Reseptor Adenovirus

Answer 10

CAR, Sialic acid, MHC Class I

Question 11

Oncogene Adeno

Answer 11

E1A, E1B

Question 12

Tipe infeksi Adeno

Answer 12

Lytic, laten, transforming

Question 13

Adeno umumnya menyerang..

Answer 13

Anak 6 bulan - 5 tahun

Question 14

3 genus paramyxoviridae

Answer 14

1. Morbilivirus: measles (bkn resp)
2. Paramyxco: mumps (bkn resp) & influenza
3. Pneumovirus: RSV & Metapneumovirus
4. Hendra & nipah virus

Question 15

RSV Virus merupakan penyebab utama..

Answer 15

Fatal acute respiratory tract infection in infant and young children

Question 16

Tx RSV

Answer 16

Utk infant immunocompromised:

1. Ribavirin dan/ atau
2. Anti RSV immunglobulin

Question 17

Setelah RSV virus menginfeksi resp dan membentuk .., kemudian bentukan tsb menginvasi… dan menjadi..

Answer 17

Syncytia, epitel, multinucleated giant cell

Question 18

Penyebab tersering kedua fatal acute RT inf in infant & young children

Answer 18

Parainfl virus

Question 19

MK parainfl virus

Answer 19

1. Bayi - dewasa: laringitis/ croup
2. Anak: pneumonia
3. Bayi & anak: tracheobronchitis

Question 20

Sifat berikut termasuk (ortho/ para)

1. Rnase sensitif
2. Replikasi sitoplasma
3. Replikasi nukleus
4. Fusi membran plasma
5. Stabil
6. Fusi endosome
7. Highly antigenic

Answer 20

1. O
2. P
3. O
4. P
5. P
6. O
7. O

Question 21

antiviral yang digunakan untuk influenza A dan B dengan cara menghambat neuraminidase pada permukaan virus

Answer 21

Oseltamivir & Zanamivir

Question 22

Orthomyxo dibagi menjadi… berdasarkan..

Answer 22

3 tipe (A,B,C), antigen protein struktural, core antigen

• Hemaglutinin & neuraminidase pada envl akan dibagikan subtipe

Question 23

Ortho yang ada pada manusia..

Answer 23

B & C

Question 24

Ortho yang paling membahayakan manusia

Answer 24

A (Mutasi genetik tertinggi, shift & drift)

B

Question 25

Peran hemaglutinin dalam antigen

Answer 25

Attachment, fusi, target neutralizing antibody

Question 26

Peran neuraminidase dalam antigen

Answer 26

Promotes virus release (diblock oleh osel & zana)

Question 27

Peran M2 protein dalam antigen

Answer 27

Uncoating & viral release (diblock amantadine rimantadine)

Question 28

Penularan ortho melalui..

Answer 28

Inhalasi yg tercemar kotoran unggas terinfeksi

Question 29

Spesimen ortho (sekre, swab hidung, swab faring dsb) dikirim pada suhu..

Answer 29

40 celcius

Question 30

Bila suspek ortho maka..

Answer 30

Ambil 3 hari berurutan, ambil darah untuk PMK

Question 31

Reye syndrome

Answer 31

Komplikasi influenza; berupa acute encephalopathy & disfungsi hepar

Question 32

Masa inkubasi rhinovirus

Answer 32

1-4 hari

Question 33

Dugaan coronavirus didasarkan pada..

Answer 33

>1 gejala pernapasan | >10 hari ke daerah endemis/ pernah kontak

Question 34

Periode inkubasi RSV

Answer 34

2-8 hari

Question 35

Virus H5N1 termasuk..

Answer 35

Orthomyxovirus

Question 36

Grup.../ sub group 1 memiliki kemampuan untuk..

Answer 36

Aglutinasi eritrosit manusia