4: Alcohol and the CNS Flashcards Preview

CLASP: Alcohol 2017/18 > 4: Alcohol and the CNS > Flashcards

Flashcards in 4: Alcohol and the CNS Deck (24)
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1
Q

Alcohol is (clear / coloured) with a (pleasant / unpleasant) odour.

A

clear

pleasant

2
Q

Alcohol is aliphatic - what does this mean?

A

Forms chains, not aromatic rings

3
Q

Is alcohol soluble?

A

Yeah

4
Q

What is the functional group found in alcohol?

A

Hydroxyl

-OH

5
Q

What kind of bonding does the hydroxyl group of ethanol give rise to?

A

Hydrogen bonding

6
Q

Does ethanol have any isomers?

A

No

7
Q

Ethanol is well absorbed by the ___ route.

A

oral

8
Q

20% of ethanol absorption occurs in the ___.

The other 80% occurs in the ___ ___.

A

stomach

small intestine

9
Q

Ethanol has the capacity to produce which effect?

A

General anaesthesia

10
Q

As the number of carbons in an alcohol molecule increases, the greater their ability to act as a ___ ___.

What is this rule called?

A

general anaesthetic

Meyer-Overton Rule

11
Q

Are alcohols used as a general anaesthetic in humans?

A

No

jesus christ

12
Q

What is the cut-off point for the general anaesthetic effects of n-alcohols?

A

Hexanol (6) - pentanol (8)

Then it starts to decrease

13
Q

What effects does alcohol have in mice?

A

Loss of righting reflex (can’t adjust to changes from upright)

Ataxia (difficulty walking)

14
Q

Ethanol affects which two types of neurotransmitter in the CNS?

A

Excitatory

Inhibitory

15
Q

Which excitatory neurotransmitter does ethanol affect?

A

Glutamate

16
Q

Which inhibitory neurotransmitters are affected by ethanol?

A

GABA

Glycine

17
Q

Excitatory neurotransmitters such as ___ allow the entry of ___ ions.

What effect does this have on the membrane potential?

A

glutamate , sodium

depolarisation

18
Q

Inhibitory neurotransmitters such as ___ or ___ allow the entry of ___ ions.

What effect does this have on the membrane potential?

A

GABA or glycine , chloride

hyperpolarisation

19
Q

Glutamate triggers an ____ action potential.

A

excitatory

20
Q

GABA and glycine trigger an ____ action potential.

A

inhibitory

21
Q

Ethanol’s effects on excitatory and inhibitory neurotransmitters is thought to cause one of its main effects, which is ___ ___.

A

CNS depression

22
Q

Lots of proteins have cavities specifically “designed” for the binding of ___.

A

ethanol

23
Q

What is the drink-drive limit in BAC?

A

0.05g / 100ml blood

i.e 0.05

24
Q

(See BAC chart for effects on behaviour at different blood alcohol concentrations.)

A