Flashcards in 4. Chrissobolis - DM Drugs Deck (71)
What drug class does Metformin belong to?
What is the main function of Metformin?
Reduce hepatic glucose production
What are 2 the minor functions of Metformin?
1. Increase glucose uptake and utilization in skeletal muscle and adipose
2. Decrease glucose absorption in the GI tract
What is the main reason for Metformin therapy? - two things
1. Lower glucose levels
2. Improve insulin sensitivity
What does Metformin do at the cellular level?
Increases AMP, causing an increase in insulin sensitivity and a decrease in gluconeogenic pathways
What are the 5 brand name available formulations of Metformin? What 3 are extended release?
2. Rio met
3. Fortamet - ER
4. Glucophage XR - ER
5. Glumetza - ER
What is the black box warning for Metformin?
What 3 conditions is Metformin not indicated for?
2. Diabetic ketoacidosis
3. Heart Failure
What is the main action of TZDs?
Decrease insulin resistance
What is TZDs MOA?
Selective ligand for PPAR-y receptor
What is TZDs action in adipose tissue?
Increase FFA uptake and storage
What is TZDs action in the liver?
Enhances insulin signaling
What is TZDs action in macrophages?
Affects M2 and M1, promotes anti-inflammatory macrophages and protects against pro-inflammatory macrophages
What is the brand name of Pioglitazone? What class does it belong to?
Actos - TZD
What is the brand name of rosiglitazone? What class does it belong to?
Avandia - TZD
What are the three main side effects of TZDs?
1. Fractures in bones
2. HTN and edema
3. HF and MI
What is the brand name (hint, there's 2) of Exenatide? What drug class does it belong in?
Bydureon and Byetta - Short Acting GLP-1Ra
Why are long acting GLP-1Ra better than short acting GLP-1Ras?
Better overall glycemic control due to higher fasting insulin levels
What is the brand name (hint there's 2) for liraglutide? What drug class does it belong it?
Saxenda, Victoza - long acting GLP-1Ra
What is the brand name for albiglutide? What drug class does it belong to?
Tanzeum - long acting GLP-1Ra
What is the brand name for dulaglutide? What drug class does it belong to?
Trulicity - long acting GLP-1Ra
Where is metformin's main site of action?
In the liver
What is the MOA of DPP4i?
Inhibit the breakdown of GLP-1 and GIP by DPP4.
What is the brand name for sitaglpitin? What drug class does it belong to?
Januvia - DPP4i
What is the brand name for saxagliptin? What drug class does it belong to?
Onglyza - DPP4i
What is the brand name for linagliptin? What drug class does it belong to?
Trajenta - DPP4i
What is the brand name for alogliptin? What drug class does it belong to?
Nesina - DPP4i
What are the main SE of DPP4is?
Severe joint pain and increased risk of acute pancreatitis
What is the MOA of sulfonylureas?
Increase insulin release by biding to SUR1 receptor on pancreatic beta cells