Tumor suppressor genes and syndromes

Question 0

WT1

Syndrome:
Tumor:

Answer 0

S: Familial Wilms tumor
T: Wilms tumor

Question 1

Rb

Syndrome:
Tumor:

Answer 1

S: Retinoblastoma
T: Retinoblastoma

Question 2

NF1

Syndrome:
Tumor:

Answer 2

S: Neurofibromatosis type 1
T: neurofibroma, sarcoma

Question 3

NF2

Syndrome:
Tumor:

Answer 3

S: Neurofibromatosis type 2
T: schwannoma, meningioma

Question 4

APC

Syndrome:
Tumor:

Answer 4

S: Familial adenomatosis polyposis
T: tumor of colon, stomach, and intestine

Question 5

p53

Syndrome:
Tumor:

Answer 5

S: Li-Fraumeni syndrome
T: breast, lung, brain, sarcoma

Question 6

VHL

Syndrome:
Tumor:

Answer 6

S: von Hippel-Lindau disease
T: kidney, adrenal

Question 7

E-CAD

Syndrome:
Tumor:

Answer 7

S: Familial gastric cancer
T: stomach, breast

Question 8

PTCH

Syndrome:
Tumor:

Answer 8

S: Gorlin syndrome
T: Basal cell carcinoma

Question 9

PTEN

Syndrome:
Tumor:

Answer 9

S: Cowden syndrome
T: Hamartoma

Question 10

MEN1

Syndrome:
Tumor:

Answer 10

S: Multiple endocrine neoplasia
T: pituitary, pancreas, parathyroid