15- GI III

Question 1

idiopathic chronic relapsing disorder

Answer 1

IBS

Question 2

with IBS treatment you activate 5HT4 receptors but block 5HT3 receptors- why? ***

Answer 2

+ 5HT4 = promote NT release in ENS resulting in motility AND decrease firing of extrinisc sensory neurons to the CNS to block pain

• 5HT3 = block visceral pain, motility, and secretion

Question 3

two drugs used for IBS

Answer 3

tegaserod and alosetron

Question 4

treatment for diarrhea prominent IBS

Answer 4

alosetron

Question 5

treatment for constipation predominant IBS

Answer 5

tegaserod

Question 6

MOA tegaserod

Answer 6

5HT4 partial agonist

Question 7

MOA alosetron

Answer 7

5HT3 antagonist

** women only

Question 8

first line agent for mild to moderate ulcerative colitis

Answer 8

sulfasalazine and mesalamine

*** sulfasalazine has very adverse effects

Question 9

what type of drugs are sulfasalazine and mesalamine?

Answer 9

aminosalicylates

Question 10

treatment of moderate to severe ACTIVE IBD

Answer 10

prednisone

Question 11

maintenance of remission of IBD

Answer 11

azathioprine

Question 12

maintenance of remission of Chron’s

Answer 12

methotrexate

Question 13

treat moderate to severe IBD

Answer 13

infliximab