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Pharmacology > Adrenergic Agonists and Antagonists > Flashcards

Adrenergic Agonists and Antagonists Flashcards

1
Q

Epinephrine

Low dose physiological effects

A 
Lower diastolic BP (B2)
Increase CO (B1)
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2
Q

Epinephrine

High dose physiological effects

A

Increase TPR and CO (A1, A2, B1)
Bronchodilation (B2)
Decreased bronchial secretions (A1)

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3
Q

Epinephrine

Toxicity

A 
Arrhythmias
cerebral hemorrhage
anxiety
cold extremities
pulmonary edema
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4
Q

Epinephrine

Indiciations

A

Anaphylaxis
Cardiac Arrest
Bronchospasm

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5
Q

Norepinephrine

Physiological Effects

A 
Increase CO (B1)
Increase TPR (A1, A2) 
Decrease HR (baroreflex)
Overall increase MAP
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6
Q

Norepinephrine

Toxicity

A

Ischemia
Arrhythmias
HTN

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7
Q

Norepinephrine

Indications

A

Shock

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8
Q

Norepinephrine

Contraindications

A

Preexisting ischemic or vasoconstriction

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9
Q

Isoproterenol

Physiological Effects

A 
Nonspecific B agonist
Decrease TPR (B2)
Increase CO (B1)
Small decrease in MAP
Bronchodilation (B2)
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10
Q

Isoproterenol

Indications

A

Bradycardia/heart block when TPR is high

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11
Q

Iroproterenol

Toxicity

A

Tachyarrhythmias

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12
Q

Isoproterenol

Contraindications

A

Angina with arrhythmias

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13
Q

Dobutamine

Physiological Effects

A 
Selective B1 agonist
Increase CO (B1)
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14
Q

Dobutamine

Toxicity

A

Hypotension (B2)

Arrhythmias (B1)

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15
Q

Dobutamine

Indications

A

Short term Rx for CHF or cardiogenic shock

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16
Q

Dopamine
Physiological Effects
Low Dose

A 
Decrease TPR (D1 - vasodilation of renal and splanchnic circulation)
Increases CO (B1)
17
Q

Dopamine
Physiological Effects
High dose

A

Increases MAP and TPR (A1, A2, B1)

18
Q

Dopamine

Toxicity

A 
Low BP (low infusion rates)
Ischemia (high infusion rates)
19
Q

Dopamine

Indications

A

Cardiogenic Shock

20
Q

Dopamine

Contraindications

A

Tachyarrhythmias

Ventricular fibrillation

21
Q

Alpha-1 receptors located?

A

Vascular smooth muscle (contraction)

Pupillary dilation

22
Q

Alpha-2 receptors located?

A

Adrenergic and cholinergic nerve terminals (inhibit NT release)

23
Q

Beta-1 receptors located?

A 
Heart (cardiac myocytes and SA pacemaker cells)
Juxtaglomerular apparatus (increase renin release)
24
Q

Beta-2 receptors located?

A

Vascular smooth muscle
Uterine smooth muscle
Respiratory smooth muscle
DILATION

Pharmacology (67 decks)

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