Last Minute PsychoPharm

Question 1

Basis MOA for…

1. Abetacept
2. Rituximab
3. Anakinra
4. Tocilizumab
5. Tofacitinib

Answer 1

1. CTLA4 agonist
2. CD20 antagonist, depletes B cells
3. IL-1 antagonist
4. IL-6 antagonist
5. small molecule JAK inhibitor

Question 2

Which SGAs don’t cause any weight gain or metabolic syndrome?

Answer 2

Ziprasidone

Question 3

Which SGAs cause no/almost no DA side effects?

Answer 3

Quetiapine and Clozapine

Question 4

Ziprasidone

Side Effects

Answer 4

No M1 side effects or weight gain

Increased qTc interval

Question 5

Risperidone

Side Effects

Answer 5

No M1 or H1 related side effects

Question 6

Which anti-RA drug may cause ocular toxicity?

Answer 6

Hydroxychloroquine

Question 7

How to treat cocaine withdrawal

Answer 7

Bromocriptine (dopamine agonist)

Benzodiazepines (lorazepam)

Question 8

Alcohol’s effects on NS

Answer 8

Decreases glutamate
Increases GABA activity

Upregulates NMDA receptors over long time

Question 9

Varenicline

MOA

Answer 9

Chantix!

Nicotine receptor partical agonist that has a higher affinity (thus decreasing the reward of smoking and decreasing nicotine withdrawal)

Question 10

LSD and Mescaline

MOA

Answer 10

Bind 5HT 2A receptors in cortex

Question 11

Treatment of LSD or Mescaline toxicity

Answer 11

Nonpsychotic agitation – diazepam

Severe agitation – antipsychotics

Question 12

Buspirone
MOA
Half life
Indications
Shouldnt be used with...

Answer 12

Partial 5HT 1A agonist
Short half life (2.5 hours)

Indications: Anxiety disorders, major depression

Should NOT be used with MAOIs (risk serotonin syndrome)