Clindamycin

Question 1

Clindamycin

Mechanism of Action

Answer 1

Binds 50S ribosomal subunit to inhibit protein synthesis

Question 2

Clindamycin is bacteri______

Answer 2

Bacteriostatic

May be cidal at very high concs against susceptible arganisms

Question 3

Clindamycin

Mechanisms of Resistance

Answer 3

Altered target sites at 50S subunit- erm gene

Active efflux
mef gene conferring macrolide resistance

Question 4

Clindamycin

Spectrum of Activity

Answer 4

Only active against Gram Positive bacteria and anaerobes!

MSSA, CA-MRSA, PSSP, Group and viridians strep

Bacteroides, Clostridium (not C diff), actinomyces

Question 5

Clindamycin

Absorption

Answer 5

IV or PO (F=90%)

Question 6

Clindamycin
Distribution

Does it get into the CSF?

Answer 6

Good serum concs and tissue penetration

Little CSF penetration

Question 7

Clindamycin

Elimination

Answer 7

Primarily metabolized by the liver

Question 8

Clindamycin

Clinical Uses

Answer 8

Anaerobic infections outside the CNS
Skin and soft tissue infections
Alternative therapy for C perfringens, PCP, toxoplasmosis

Question 9

Clindamycin

Adverse Effects

Answer 9

GI - nausea, vomit, diarrhea
May induce C diff infection
Hepatotoxicity (rare)
Allergy
Neutropenia/thrombocytopenia (rare)