410-412 - Cell junctions, shoulders, knees, and wrists Flashcards Preview

Alex's First Aid Cards > 410-412 - Cell junctions, shoulders, knees, and wrists > Flashcards

Flashcards in 410-412 - Cell junctions, shoulders, knees, and wrists Deck (48)
Loading flashcards...
1

Name the layers of the epidermis

Stratum Corneum (keratin)
Stratum Lucidum
Stratum Granulosum
Stratum Spinosum (spines = desmosomes)
Stratum Basale (stem cell site)

Californians Like Girls in String Bikinis

2

What proteins make up tight junctions?

claudins and occludins

3

What is another name for tight junction?

zonula occludens

4

What is the function of the tight junction?

prevents paracellular movement of solutes

5

Are tight junctions located near the apical or BL surface of the epithelial cell junction?

Apical

6

What is another name for adherents junction?

zonula adherens

7

What kind of junction is just below the tight junction in the epithelial junction?

adherens junctions

8

What is the function of the adherents junction?

forms a "belt" connecting actin cytoskeletons of adjacent cells with CADherens (Ca2+ dependent adhesion proteins)

9

Loss of which proteins in the inter epithelial junction promotes metastasis?

E-cadherin

10

What is another name for a desmosome?

macula adherens

11

What is the function of desmosomes?

structural support via keratin interactions.

12

What disease is caused by autoantibodies against desmosomes?

pemphigus vulgaris

13

What proteins make up gap junctions?

connexons

14

What do gap junctions do?

permit electrical and chemical communication b/w cells

15

What connects keratin in basal cells to underlying basement membrane?

hemidesmosome

16

What condition is caused by autoantibodies against hemidesmosomes?

bullous pemphigoid
"hemidesmosomes are down "bullow"

17

What are membrane proteins that maintain the integrity of the BL membrane by binding to collagen and laminin in the BM?

integrins

18

What test is used to assess ACL injury?

anterior drawer sign

19

What test is used to assess PCL injury?

posterior drawer sign

20

Would you apply valgus stress or varus stress to assess an MCL injury?

valgus

21

Would you apply valgus stress or varus stress to assess an LCL injury?

varus

22

What is the McMurray test?

rotation of the knee to assess meniscal tears

23

Pain on external rotation of the knee indicates injury to which meniscus?

medial meniscus

24

Pain on internal rotation of the knee indicates injury to which meniscus?

lateral meniscus

25

What is the unhappy triad?

a common injury in contact sports due to the lateral force applied to a planted leg; classically damage to ACL, MCL, and medial meniscus (attached to MCL); note that lateral meniscus injury is more common

26

Do "anterior" and "posterior" in ACL and PCL refer to sites of tibial or femur attachment?

tibial

27

Is the fibula medial or lateral at the knee joint?

lateral

28

What is an important bony landmark for pudendal nerve block (e.g. to relieve pain of delivery)?

ischial spine

29

Where is the appendix located with respect to external anatomy?

2/3 of the distance b/w the umbilicus and the anterior superior iliac spine (McBurney point)

30

What is an important landmark for a lumbar puncture?

iliac crest