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2nd U1 Pharm > Rheumatoid Arthritis and Gout Drugs list > Flashcards

Rheumatoid Arthritis and Gout Drugs list Flashcards

1
Q

Name the non-selective NSAIDs…

A

Indomethacin

Naproxen

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2
Q

Name the selective NSAIDs…

A

COX-2 inhibitors

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3
Q

What are the therapeutic uses of Indomethacin and Naproxen?

A

Rheumatoid arthritis and acute gouty arthritis

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4
Q

What are the therapeutic uses of COX-2 inhibitors?

A

Superseding conventional NSAIDs for rheumatoid arthritis

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5
Q

What are the 2 mechanisms of action for Indomethacin, Naproxen, and COX-2 inhibitors?

A

Eliminate pain and reduce inflammation

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6
Q

What are 2 non-selective NSAIDs and one selective NSAID used for the elimination and pain and reduction of inflammation?

A

Indomethacin and Naproxen are non-selective

COX-2 inhibitors are selective

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7
Q

Name the two main side effects seen from indomethacin and Naproxen… What alternative drug can be used to reduce these side effects?

A

Gastric and duodenal ulcers

COX-2 inhibitor– 50% fewer gastric and duodenal ulcers than traditional NSAIDs

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8
Q

Name the 5 Disease-modifying antirheumatic drugs (DMARDs)?

A 
Quinolones
Glucocorticoids
Sulfasalazine
Methotrexate
Leflunomide
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9
Q

Which of the Disease-modifying antirheumatic drugs (DMARDs) is used for both rheumatoid arthritis and SLE?

A

Quinolones

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10
Q

Which of the Disease-modifying antirheumatic drugs (DMARDs) is used for both rheumatoid arthritis and acute gouty arthritis?

A

Glucocorticoids

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11
Q

What is the major side effect of Quinolones?

A

Retinal damage

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12
Q

When patients no longer respond to NSAIDs or can’t tolerate other Disease-modifying antirheumatic drugs (DMARDs), which Disease-modifying antirheumatic drugs (DMARDs) is indicated?

A

Quinolones

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13
Q

What is the mechanism for Quinolones?

A

Reduces T-cell activation and chemotaxis

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14
Q

Which Disease-modifying antirheumatic drugs (DMARDs) inhibit phospholipase A2–inhibiting the formation of prostaglandins and also inhibits cytokine production preventing induction of COX-2?

A

Glucocorticoids

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15
Q

What Disease-modifying antirheumatic drugs (DMARDs) inhibits the release of IL-1 and TNF-a?

A

Sulfasalazine

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16
Q

Which Disease-modifying antirheumatic drugs (DMARDs) inhibits aminoimidazolecarboxamide transformylase and thymidylate synthetase and also causes adenosine accumulation inhibiting inflammation?

A

Methotrexate

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17
Q

Which Disease-modifying antirheumatic drugs (DMARDs) inhibits dihydroorotate dehydrogenase, which inhibits T-lympocyte response to stimuli?

A

Leflunomide

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18
Q

Name the major side effects of Glucocorticoids…

A

Cushingoid symptoms

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19
Q

What are the major side effects of Sulfasalazine?

A

N/V, skin rashes, neutropenia

Headaches can also occur

20
Q

What are the major side effects of Methotrexate?

A

Nausea, stomatitis, hepatotoxicity

21
Q

What are the major side effects of Leflunomide?

A

Diarrhea, hepatotoxicity

22
Q

Which Disease-modifying antirheumatic drugs (DMARDs) is considered the gold standard of therapy for Rheumatoid arthritis?

A

Methotrexate

23
Q

Name the 10 biologic response modifiers used to treat Rheumatoid arthritis…

A 
Etanercept
Infliximab
Adalimumab
Golimumab
Certolizumab
Anakinra
Tocilizumab
Rituximab
Abatacept
Tofacitinib
24
Q

Name the 5 Biologic response modifiers that block binding of TNF to TNF receptors to help treat Rheumatoid arthritis…

A 
Etanercept
Infliximab
Adalimumab
Golimumab
Certolizumab
25
Q

What is the mechanism of action for Anakinra, used in the treatment of Rheumatoid arthritis?

A

IL-1 receptor antagonist

26
Q

What is the mechanism of action for Tocilizumab, used in the treatment of Rheumatoid arthritis?

A

IL-6 Receptor antagonist

27
Q

Which biologic response modifier used to treat rheumatoid arthritis is anti-CD20 mAB reducing the number of circulating B cells?

A

Rituximab

28
Q

Which biologic response modifier used to treat rheumatoid arthritis inhibits T-cell activation and induces T-cell apoptosis?

A

Abatacept

29
Q

Which biologic response modifier used to treat rheumatoid arthritis inhibits JAK 1 & 3 inhibiting production of inflammatory mediators?

A

Tofacitinib

30
Q

What are the side effects seen with Infliximab?

A

Antigenic response to murine monoclonal Ab

31
Q

What are the side effects seen with Golimumab?

A

Risk of serious infections

32
Q

What are the side effects seen with Certolizumab?

A

Risk of serious infections

33
Q

What are the side effects seen with Rituximab?

A

Infections

Hypersensitivity reactions

34
Q

What are the side effects seen with Adatacept?

A

Headaches

Infections

35
Q

Where are the side effects seen with Tofacitinib?

A

Upper respiratory tract infections
Headaches
Diarrhea

36
Q

What drug is used to treat acute gouty arthritis, works within 12-24 hours and prevents tubular polymerization leading to inhibition of leukocyte migration, phagocytosis, and release of cytokines?

A

Colchicine

37
Q

What are the side effects of long-term use of Colchicine?

A

peripheral neuropathy and neutropenia

Also can cause N/V, abdominal pain, diarrhea

38
Q

What uricosuric agent is used in the treatment of chronic tophaceous gout?

A

Probenecid

39
Q

Which drug used in the treatment of chronic tophaceous gout competes with rate at the anionic transport site od the renal tubule and inhibits rate reabsorption?

A

Probenecid

40
Q

What are the side effects seen with Probenecid?

A

Urate crystal mobilization and acute gouty arthritis

Also can cause GI irritation

41
Q

What drug reduces uric acid synthesis by inhibiting xanthine oxidase to alloxanthine in treatment of Chronic tophaceous gout?

A

Allopurinol

42
Q

What are the side effects seen with Allopurinol?

A

Acute attacks of gouty arthritis early in treatment due to mobilization of rate crystals

43
Q

What drug is a non-purine, non-competitive antagonist of xanthine oxidase used in the treatment of chronic tophaceous gout?

A

Febuxostat

44
Q

What are the side effects seen with Febuxostat?

A

Nausea
Rash
Arthralgias

45
Q

A recombinant stabilized fricassee used to convert uric acid to allantoin used in the treatment of chronic tophaceous gout is?

A

Pegloticase

2nd U1 Pharm (11 decks)

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