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2nd U1 Pharm > CYP enzymes > Flashcards

CYP enzymes Flashcards

1
Q

What is a prodrug?

A

medication that is administered in an inactive or less than fully active form

Converted to its active form through a normal metabolic process

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2
Q

What is induction?

A

Biotransformation by induced CYP enzymes

Results in either

increased activity of a prodrug
or
Enhanced elimination of drugs

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3
Q

What is inhibition?

A

Results in

Increased bioavailability of a drug
Or
Decreased activity of a prodrug

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4
Q

Name the drugs that are metabolized by 1A2…

A

Caffeine

Theophylline

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5
Q

Name the inhibitors of 1A2…

A

Grapefruit juice

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6
Q

Name the inducers of 1A2…

A

Smoking

Charred food

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7
Q

Name the drugs that are metabolized by 2C9…

A

Phenytoin

Warfarin

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8
Q

Name the inhibitors of 2C9…

A

Macrolides

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9
Q

Name the inducers of 2C9…

A

Rifampicin

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10
Q

Name the drugs that are metabolized by 2C19…

A

Diazepam

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11
Q

Name the inhibitors of 2C19…

A

Fluoxetine

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12
Q

Name the inducers of 2C19…

A

St. John’s wart

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13
Q

Name the drugs that are metabolized by 2D6…

A

Codeine

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14
Q

Name the inhibitors of 2D6…

A

Quinidine

Haloperidol

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15
Q

Name the inducers of 2D6…

A

St, John’s wart

Rifampin

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16
Q

Name the drugs that are metabolized by 2E1…

A

Paracetamol

17
Q

Name the drugs that are metabolized by 3A4…

A

Terfenadine

Verapamil

18
Q

Name the inhibitors of 3A4…

A

Ketoconazole

Itraconazole

19
Q

Name the inducers of 3A4…

A

St. John’s wart

20
Q

2C9 is a _____ and is seen in what 3 ethnic groups?

A

Poor metabolizer

African americans
Asians
Whites

21
Q

2C19 is a ______ and is seen in what 3 ethnic groups?

A

Poor metabolizer

African americans
Asians
Whites

22
Q

2D6 is a ___ in what ethnic groups and a _____ in what ethnic groups?

A

Poor metabolizer

African americans
Asians
Whites

Ultra extensive metabolizer

Asians
Ethiopians
Northern and Southern Europeans

2nd U1 Pharm (11 decks)

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