antigen receptor diversity and lymphocyte development Flashcards
1
Q
clonal selection theory
A
individual possesses clonally derived lymphocytes
2
Q
B cell receptor has what two major parts
A
- SIG - surface immunoglobin for antigen recognition
2. Ig alpha and beta
3
Q
what does SIG do
A
bind to antigen
4
Q
what does Ig alpha and beta do
A
signal transduction
5
Q
What are three parts to T-cell receptor
A
- TCR alpha and beta
- CD3 subunits
- wierd greek letter chain
6
Q
what does TCR alpha beta do
A
binds to MHC-antigen peptide complex
7
Q
what does CD3 subunit do
A
signal transduction
8
Q
weird chains do what
A
signal transduction
9
Q
what determines antigen specificity for Ab (antibody)
A
variable domains of IgH and L chains
10
Q
what determines the antigen specificity of TCR alpha beta
A
variable domains of TCR alpha and beta
