Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Elsevier Hematology (RVSP) > 2. Hemoglobin > Flashcards

2. Hemoglobin Flashcards

1
Q

Place where heme is synthesized

A

Mitochondria

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Composition of a normal Hgb

A
  • 4 heme molecules

- 4 globin molecules

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

RBC stages that produce hemoglobin

A
  • Pronormoblast
  • Basophilic normoblast
  • Polychromatophilic normoblast
  • Orthochromic normoblast
  • Reticulocyte
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Composition of the globin portion of Hgb

A
  • 2 α chains

- 2 non-α chains

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Globin chains controlled by Chromosome 16

A

α & ζ chains

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Globin chains controlled by Chromosome 11

A

β, γ, δ, and ε chains

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Function of Hgb

A

Transport of gases

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

The primary Hgb for gas transport in the body

A

Oxyhemoglobin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Hgb variant that contains Fe3+ instead of Fe2+

A

Methemoglobin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Heme is composed of

A
  • protoporphyrin IX ring

- Fe2+

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Methemoglobin production is controlled by

A

Methemoglobin reductase pathway

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Hgb variant formed as a result of oxidation of Hgb by materials containing sulfur

A

Sulfhemoglobin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Hgb variant that can lead to cyanosis

A

Sulfhemoglobin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Hgb variant resulting from heme iron-binding carbon monoxide

A

Carboxyhemoglobin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Hgb variant that has a high O2 affinity; will not give up O2 to tissues to the tissues easily

A

Carboxyhemoglobin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Process of energy production utilized by RBCs

A

Anaerobic glycolysis: Embden-Meyerhof pathway

17
Q

Functions of the Embden-Meyerhof pathway

A
  • maintain cation gradients
  • maintain RBC membrane flexibility
  • supply offshoot pathways
18
Q

3 offshoot pathways of the Embden-Meyerhof pathway

A
  • hexose monophosphate shunt
  • methemoglobin reductase pathway
  • Rapoport-Luebering pathway
19
Q

Embden-Meyerhof pathway offshoot; protection of the RBC from oxidant damage by production of reduced glutathione

A

Hexose monophosphate shunt

20
Q

Embden-Meyerhof pathway offshoot; maintains iron in the ferrous form

A

Methemoglobin reductase pathway

21
Q

Embden-Meyerhof pathway offshoot; regulation of O2 delivery to tissues by the production of 2,3-bisphosphoglycerate (2,3-BPG)

A

Rapoport-Luebering pathway

22
Q

Produced in hexose monophosphate shunt for protection of RBCs from oxidant damage

A

Reduced glutathione

23
Q

Produced in the Rapoport-Luebering pathway for regulation of O2 delivery

A

2,3-BPG

24
Q

Hgbs found during the embryonic stage

A

Gower 1
Gower 2
Portland

25
Q

Hgbs found during the fetal stage

A

Hgb F
Hgb A
Hgb A2

26
Q

Hgbs found during adult stage

A

Hgb A
Hgb A2
Hgb F

27
Q

Globin chains of Gower 1

A

2ζ & 2ε

28
Q

Globin chains of Gower 2

A

2α & 2ε

29
Q

Globin chains of Portland

A

2ζ & 2γ

30
Q

Globin chains of Hgb F

A

2α & 2γ

31
Q

Globin chains of Hgb A

A

2α & 2β

32
Q

Globin chains of Hgb A2

A

2α & 2δ

Elsevier Hematology (RVSP) (12 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions