Antiinflammatory Drugs (NSAIDs)

Question 1

salicylic acid (aspirin)

Answer 1

-treats: headaches
-AE’s:
GI: heartburn, nausea, GI bleeding, mucosal lesions/ulcers

Renal: reduction in creatinine clearance, acute tubular necrosis with renal failure

**Toxicity: manifests in tinnitus and hearing loss

Question 2

ketorolac

Answer 2

• acetic acid derivative
• treats: moderate - acute pain; not chronic

AE’s:

GI: heartburn, nausea, GI bleeding, mucosal lesions/ulcers

Renal: reduction in creatinine clearance, acute tubular necrosis with renal failure

*renal impairment, GI pain, dyspepsia (indigestion)

Question 3

ibuprofen

Answer 3

• propionic acid derivative
• treats: pain (RA, osteoarthritis, gout); fever

AE’s:

GI: heartburn, nausea, GI bleeding, mucosal lesions/ulcers

Renal: reduction in creatinine clearance, acute tubular necrosis with renal failure

*nausea, vomiting, headache

Question 4

naproxen

Answer 4

-treats: pain, fever (w/ fewer SA and HTN meds)
AE’s:

GI: heartburn, nausea, GI bleeding, mucosal lesions/ulcers

Renal: reduction in creatinine clearance, acute tubular necrosis with renal failure

*nausea, vomiting, headache

Question 5

cyclooxygenase-2 (COX-2)

Answer 5

• *celecoxib
• COX-2 inhibitor
• treats: OA, RA, acute pain, ankylosing spondylitis, primary dysmenorrhea (lady cramps)

AE’s:

GI: heartburn, nausea, GI bleeding, mucosal lesions/ulcers

Renal: reduction in creatinine clearance, acute tubular necrosis with renal failure

*HA, diarrhea, HTN

Question 6

nabumetone

Answer 6

*enolic acid derivative
-treats: OA, RA
AE’s:

GI: heartburn, nausea, GI bleeding, mucosal lesions/ulcers

Renal: reduction in creatinine clearance, acute tubular necrosis with renal failure

**decreases GI AE’s (more than other NSAIDs)