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RUSVM Virology > Circoviridae > Flashcards

Circoviridae Flashcards

1
Q

Clinical signs of Porcine Dermatitis and Nephropathy Syndrome (PDNS)

A

Necrotizing skin lesions

Necrotizing vasculitis

Necrotizing and fibrinous glomerulonephritis

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2
Q

Etiology of Chicken Infectious Anemia

A

Chicken Anemia VIrus (CAV)

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3
Q

Etiology of Post Weaning Multisystemic Wasting Syndrome (PMWS)

A

Porcine Circovirus 2

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4
Q

Circovirus viral DNA replication occurs in

A

the nucleus

_____________________

Requires cellular proteins and other components produced during the S phase of the cell cycle

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5
Q

Common co infections associated with Post weaning multisystemic wasting syndrome

A

Porcine Parvovirus

Porcine Reproductive and Respiratory Virus

SIV

Mycoplasma hyopneumoniae

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6
Q

Diagnosis of Circovirus

A

Clinical Signs

Samples

Histopathology

Serological Assays

PCV2 nucleic acids by PCR

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7
Q

Diagnosis of Chicken Infectious Anemia

A

Clinical Signs

Examination of blood

Necropsy

Histopathology

Serology

Virus isolation

PCR

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8
Q

Vaccination for Post weaning multisystemic wasting syndrome

A

Chimeric Vaccine - utilize the non pathogenic porcine circovirus 1 as a genetic backbone for expression of immunogenic capsid protien of PCV2

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9
Q

Diseases associated with genus gyrovirus

A

Chicken Infectious Anemia

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10
Q

Transmisison of Post weaning multisystemic wasting syndrome

A

Fecal-Oral Transmission

Virus found in all secretions

Vertical Transmission - Transplacental transmission

Stable and survies on fomites

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11
Q

Host of Chicken Infectious Anemia

A

Highly contagious disease of young chickens

________________

2-4 weeks of age

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12
Q

Distribution of post weaning multisystemic wasting syndrome (PMWS)

A

Worldwide

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13
Q

Clinical signs of post weaning multisystemic wasting syndrom

A

Subclinical infection is most common

Lethargy, weight loss, cough, dyspnea, slow growth, lymphadenopathy, diarrhea, skin discoloration, congenital tremors, icterus

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14
Q

Describe the genome of Genus Gyrovirus

A

Circular, Single stranded negative sense DNA

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15
Q

Clinical signs of Chicken Infectious Anemia

A

Chicks are anorectic, lethargic, depressed, reduced body weight, and pale

Blood may be watery and clot slowly

PCV low

Subcutaneous hemorrhages, skeletal hemorrhages and pale muscles

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16
Q

Characteristics of Porcine Dermatitis and Nephropathy Syndrome (PDNS)

A

Sporadic

Reported in older piglets

17
Q

Transmission of Chicken Infectious Anemia

A

Virus shed in feces and feather dander

Horizontal transmission through inhalation or oral exposure

Vertical transmission through egg

Environmentally stable

18
Q

Morphology of Chicken Infectious Anemia Virus

A

12 Trumpet like structures that are less obvious in other circoviruses

19
Q

Porcine Circovirus 2 primarly targets

A

Cardiomyocytes

Hepatocytes

Macrophages - fetal life

Monocytes - post natal life

20
Q

Apoptin Protein

A

Protein of Chicken Anemia Virus that induces apoptosis and cause destruction of infected lymphocytes

21
Q

Etiology of Porcine Dermatitis and Nephropathy Syndrome (PDNS)

A

Porcine Circovirus 2

22
Q

Circovirus replication occurs in

A

Actively dividing cell

23
Q

Characteristics of Family Circoviridae

A

Small viruses

Circular single stranded DNA genomes

Virions are small, nonenveloped, spherical

24
Q

Effect of transplacental infection on the fetus

A

Infection during the first and second trimesters - fetal death and resorption or aborted fetuses with severe cardiace congestion

Infection during the last trimester has minimal effect on fetus

25
Q

Principal sites of Chicken Infectious Anemia Virus replication are

A

Hemocytoblasts in the bone marrow, precursor T cells in the cortex of the Thymus and dividing CD4 and CD8 cells in the spleen

26
Q

Goal for vaccinating against chicken infectious anemia

A

Protect the progeny from vaccinated breeders from early infections by means of maternally derived antibodies

27
Q

Post weaning multisystemic wasting syndrome is characterized by

A

Individual to coalescing foci of granulomatous inflammation in lymphoid tissues, lungs, liver, kidney, heart and intestines sometime with prominent botryoid intracytoplasmic inclusion bodies

28
Q

Host of Post Weaning Multisystemic Wasting Syndrome (PMWS)

A

Pigs

_____________________

Most common at 4-6 wees or age or 2-3 weeks post weaning

29
Q

Describe the genome of Genus Circovirus

A

Circular, single-stranded ambisense DNA

30
Q

Consistent feature in pigs that develop clinical post weaning multisystemic wasting syndrome

A

Lymphoid depletion and lymphopenia

RUSVM Virology (35 decks)

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