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Pharmacology > DOACs > Flashcards

DOACs Flashcards

1
Q

What is the UK brand name of dabigratran?

A

Pradaxa

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2
Q

What is the UK brand name of Rivaroxaban?

A

Xarelto

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3
Q

What is the UK brand name of apixaban?

A

Eliquis

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4
Q

What is the mechanism of action of dabigatran?

A

Direct thrombin inhibitor

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5
Q

What is the MOA of Rivaroxaban?

A

Direct factor Xa inhibitor

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6
Q

What is the MOA of Apixaban?

A

Direct factor Xa inhibitor

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7
Q

How id dabigatran excreted?

A

Mostly renal

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8
Q

How is rivaroxaban exreted?

A

Mostly Liver

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9
Q

How is apixaban exreted?

A

Mostly faecal

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10
Q

What are the NICE indications of treatment using dabigatran?

A
  • Prevention of VTE following hip/knee surgery
  • Prevention of stroke in non-valvular AF with co-morbidities:
    • Prior stroke or TIA, Age >=75 years, HTN, DM, HF.
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11
Q

What are the NICE indications of treatment using Rivaroxaban?

A
  1. Prevention of VTE following hip/knee surgery
  2. Treatment of DVT and PE
  3. Prevention of stroke in non-valvular AF with co-morbidities:
    • Prior stroke or TIA, Age >=75 years, HTN, DM, HF.
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12
Q

What are the NICE indications of treatment using Apixaban?

A
  1. Prevention of VTE following hip/knee surgery
  2. Prevention of stroke in non-valvular AF with co-morbidities:
    • Prior stroke or TIA, Age >=75 years, HTN, DM, HF.
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13
Q

Describe the coagulation cascade & where oral anticoagulants fit in it?

A
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14
Q

What is considered to be the safer DOAC?

A

Apixaban (but probably due to the short half life)

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15
Q

What eGFR is Dabigatran not recommended in?

A

<30ml/min

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16
Q

What eGFR are Rivaroxaban or Apixaban not recommended in?

A

<15

17
Q

What condition is dabigatran contra-indicated in?

A

Mechanical & prosthetic heart valves.

Higher chance of bleeding and thrombotic events.

18
Q

What is the only DOAC that can be used to treat VTE or PE?

A

Rivaroxaban.

Pharmacology (96 decks)

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