Mitochondria

Question 1

Over _____ percent of mitochondrial proteins are produced in the cytoplasm.

Answer 1

90

Question 2

TIM23 uses ATP to ______ proteins while pulling them through the inner membrane.

Answer 2

denature

Question 3

_____ and ______ are crucial in mitochondrial fusion.

Answer 3

Mfn and OPA1 (mutations in these lead to optic nerve atrophy and Charcot-Marie-Tooth 2A)

Question 4

______ is another name for ATP synthase.

Answer 4

F0F1

Question 5

ATP is transported out of mitochondria via an _______.

Answer 5

ATP/ADP antiporter

Question 6

_______ proteins, induced by cell damage, permeate the mitochondrial membrane and release cytochrome c.

Answer 6

Bak/bax

Question 7

Cytochrome c binds to _______ and forms an apoptosome.

Answer 7

several cytoplasmic proteins

Question 8

These two diseases are caused by defects in mitochondrial fusion proteins:

Answer 8

1) autosomal dominant optic atrophy (OPA1)

2) Charcot-Marie-Tooth type 2A (Mfn2)

Question 9

The three mitochondrial proteases are ________.

Answer 9

mAAA, iAAA, and Lon

Question 10

Ischemic injury leads to permeation of the mitochondrial membrane by ______.

Answer 10

MPTP