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Neurobio > nov19pt1 > Flashcards

nov19pt1 Flashcards

1
Q

endolymph bathes the ___ side

A

apical

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2
Q

emdolpym has this potential relative to perilymph

A

positive 80

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3
Q

potential diff between endolymph and inside IHC

A

125

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4
Q

RMP inside IHC

A

negative 60 to negative 45

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5
Q

what brings K+ into IHC

A

ELECTRICAL driving force, despite lack of chemical gradient

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6
Q

potassium flows in from endolymph, producing depol so that ___ open

A

voltage gated Ca

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7
Q

IHC NT

A

glutamate

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8
Q

post syn of IHC receptors located

A

auditory nerve endings

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9
Q

why some IHC have RMP at negative 45

A

constitutively open potassium channels

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10
Q

proteins that form tip links

A

cadherin 23 and protocadherin 15

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11
Q

supporting evidence for tip links being needed in mechantotransduction

A

calcium chelators stop mechanotransduction (by causing proteins of tip links to dissociate)

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12
Q

spatial sensitivity of response of IHC

A

0.3nm

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13
Q

time frame of mechantsduction response in IHC

A

les than 10 microseconds

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14
Q

percent constitutivley open

A

about 15

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15
Q

potassium channels open when ___ is pushed toward ____

A

short, tall stereocilium

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16
Q

little respond if pushed

A

perpendicular

17
Q

degree of depol depends on

A

displacement of stereocilium

18
Q

depolarization is ___ to ___

A

short against tall (open potassium channel)

19
Q

depolarization direction is called the ___ direction

A

positive

20
Q

Lateral inhibition means

A

desensitize neighboring receports to sharpen response

21
Q

basilar membrane at base of cochlea repsonds better to

A

high frequencies

22
Q

at 0cm, basilar membrane responds to 20thousand Hz means at 1 cm away, responds at

A

2 thousand Hz (logarithmic scale)

23
Q

tuning curve of hair cells depends on

A

location on basilar membrane and type of channels they have

24
Q

two broad categories of deafness

A

problems with middle ear bones or problem with tip links

Neurobio (31 decks)

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