Pentose Phosphate Pathway Flashcards
What does the PPP produce?
NADPH
Ribose-5-phosphate
What is NADPH used for?
To reduce oxidized glutathione for oxidative protection
What is the PP shunt?
Ribulose-5-phosphate can go directly to glucose-6-phosphate to enter glycolysis
What is unique about the PPP?
No ATP is created or used
What is the oxidative phase?
Glucose 6-phosphate to 6-phosphogluconate (NADH created) to Ribulose-5-phosphate (NADH created)
What is the non oxidative phase?
Glucose-6-phosphate to Ribulose-5-phosphate to Glyceraldehyde-3-phosphate + Fructose-6-phosphate
What enzymes are needed for ribulose 5-phosphate in the non oxidative pathway?
Transaldolase
Transketolase
What does Transketolase need as a cofactor?
TPP vitamin B1 derivative
What is needed to convert glucose 6-phosphate to 6-phosphogluconate?
Glucose 6-P dehydrogenase
What inhibits glucose-6-phosphate dehydrogenase?
Fatty acyl CoA
NADPH
What do epinephrine and glucagon cause?
Gluconeogenesis via PEPCK
Where does gluconeogenesis not occur?
In adipose because they do not have G-6-phosphatase
What can X-linked recessive glucose-6-phosphate dehydrogenase deficiency cause?
Jaundice from excess bilirubin from dead RBC and hyperbilirubinemia that can cause Kernicterus (deposition of bilirubin in the brain)
What do glucocorticoids cause?
Everything you expect in fight or flight and anti-inflammatory effects
Effect of cortisol in liver and adipose respectively:
Liver: activates gluconeogenesis
Adipose: Inhibits glyceroneogenesis to conserve glucose
