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Theriogenology > Canine Pharmaceuticals > Flashcards

Canine Pharmaceuticals Flashcards

1
Q

Where should fresh semen be deposited in the dog?

A

Cranial vagina

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2
Q

What is a progestin that is approved for used in breeding bitches?

A

Ovaban (megestrol acetate)

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3
Q

What species can Ovaban (megestrol acetate) not be used in?

Why?

A
  • Cats

- Can cause diabetes mellitus

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4
Q

What type of dosing is required with Ovaban (megestrol acetate)?

A

Daily dosing

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5
Q

When must Ovaban (megestrol acetate) be started by in order to be effective?

A

Must be started in first 3 days of proestrus to be effective.

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6
Q

When will the next estrous cycle start after the administration of Ovaban (megestrol acetate)?

A

4-6 weeks earlier

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7
Q

Other progesterones can predispose a dog to what 2 conditions?

A
  • Cystic endometrial hyperplasia

- Pyometra

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8
Q

Progesterone needs to be in what concentration or lower range to consider supplementing?

A

3 ng/mL

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9
Q

What needs to be known in order to know when to stop supplementing?

A

When due to whelp

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10
Q

What can be used later in pregnancy that allows you to still measure P4 to see if hypoluteoidism is real or not?

A

Regumate (Altrenogest)

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11
Q

If supplementing with progesterone, ideally wait until what day?
Why?

A
  • After 45 days of pregnancy (avoid 1st trimester)

- Avoid masculinization of female pups

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12
Q

When should progesterone supplementation be removed?

Why?

A
  • 2-3 days prior to due date

- Allow cervix to relax adequately

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13
Q

What is an androgenic compound that prevents LH release by negative feedback, thereby preventing estrus?

A

Mibolerone

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14
Q

Mibolerone is contraindicated in what species?

Why?

A
  • Cats

- Liver toxicity

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15
Q

Is Mibolerone approved for use in breeding bitches?

A

No

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16
Q

What type of dosing is required with Mibolerone?

A

Daily oral dosing

17
Q

When does Mibolerone need to be started?

A

30 days prior to next anticipated cycle

18
Q

What are 2 side effects that can be seen with the use of Mibolerone?

A
  • Clitoral hypertrophy

- Vaginitis

19
Q

Is Mibolerone recommended for use in breeding bitches?

A

No

20
Q

When has mibolerone been used in bitches?

A

Used in bitches with short interestrus intervals

21
Q

Mibolerone can help to achieve an IEI of what length?

A

At least 5 months

22
Q

Before using mibolerone, make sure the bitch is not what?

A

Make sure not pregnant with baseline P4

23
Q

What is a long acting implant (6-12 months) that down regulates the pituitary-gonadal axis?

A

Deslorelin (GnRH analogue)

24
Q

What is a side effect that can be seen with “mismating” shots?

A

Pyometra

25
Q

What is given in a “mismating” shot?

A

Estrogen

26
Q

Estrogen toxicity can cause what in dogs and ferrets?

A

Bone marrow suppression

27
Q

How frequently can an estrogen shot be given?

A

Not more than once every 30 days

28
Q

What are 3 other options that can be used instead of “mismating” shots?

A
  • Spaying once in diestrus
  • Waiting until day 28-30 then abort pregnancy
  • Allow whelping
29
Q

Antiprotestins bind to what?

They have no effect on what?

A
  • Bind to progesterone receptors

- No effect on progesterone

30
Q

Aglepristone is an example of a what?

What can it be used for?

A
  • Antiprogestin

- Early “mismating” shot

31
Q

Multiple small in sections of prostaglandin will do what in the bitch or queen?

A

Lyse the CL

32
Q

What are 5 possible side effects that can be seen with prostaglandins?

A
  • Drop in blood pressure
  • Vomiting
  • Diarrhea
  • Salivation
  • Panting
33
Q

What are 3 indications for the use of prostaglandin?

A
  • Pyometra
  • Retained placenta
  • Mismating
  • Collection of males
34
Q

When is the best time to used prostaglandins?

A

During second trimester

35
Q

What are 2 prolactin inhibitors?

A
  • Bromocriptine

- Cabergoline

36
Q

Which prolactin inhibitor is a dopamine agonist?

A

Bromocriptine

37
Q

Which prolactin inhibitor is a serotonin antagonist?

A

Cabergoline

38
Q

Prolactin is luteotropic in the bitch and queen during what trimester?

A

Second trimester

39
Q

How is prolactin luteotropic?

A

CL will lyse in response to lowered prolactin levels.

Theriogenology (37 decks)

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