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Psych Boards 2023 > 5 > Flashcards

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1
Q

myasthenia gravis pathophysiology

A

Acetylcholine receptor antibodies –> weaknesswh

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2
Q

What chromosome is the mutation in Huntington’s?

A

4

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3
Q

where is the atrophy in Huntington’s?

A

caudate and cerebral atrophy

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4
Q

Tobacco is an ____ (inducer or inhibitor) of CYP ____

A

inducer of CYP 1A2

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5
Q

Grapefruit juice is an ____ (inducer or inhibitor) of CYP ____

A

inhibitor of CYP 1A2/3A4

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6
Q

Fluvoxamine juice is an ____ (inducer or inhibitor) of CYP’s ____

A

inhibitor of CYP 1A2/2C19/3A4

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7
Q

order of top 5 solid tumors that metastasize to the brain

A
  1. lung
  2. breast
  3. melanoma
  4. GI
  5. kidney
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8
Q

what age do people learn to think abstractly

A

adolescence

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9
Q

what percent of the general population has a diagnosable personality disorder

A

10-15%

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10
Q

2 types of diseases that give ring enhancing lesions on brain imaging

A

toxoplasmosis and TB

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11
Q

what’s more affected with MCA stroke - broca or wernicke’s aphasias?

A

Broca

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12
Q

Lower extremities control is in which artery distribution

A

anterior cerebral artery

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13
Q

alexia without agraphia is a stroke in which artery distribution

A

posterior cerebral artery

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14
Q

what type of variables do each of these tests use (binary vs continuous): x squared, t test, ANOVA, correlation, regression analysis

A

Xsquared - 1 binary predictor, 1 binary outcome

t test - one binary predictor, 1 continuous outcome

ANOVA - 2 or more binary predictors, 1 continuous outcome

Correlation - 1 continuous predictor, 1 continuous outcome

Regression analysis - 2 or more continuous predictors, 1 continuous outcome

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15
Q

which childhood disorder is this - pectus excvatum, ocular lens dislocation, Marfans habitus, mental retardation, scoliosis, spasticity, seizures, high risk of stroke

A

homocystinuria

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16
Q

what is this childhood disorder - normal first 6 months, then becomes blind, deaf, unable to swallow, and eventually paralysis and death by age 4

A

Tay Sachs

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17
Q

Niemann-Pick disease is mutation in which enzyme

A

sphingomyelinase

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18
Q

Niemann-Pick symptoms

A

hepatosplenomegaly, thrombocytopenia, ataxia, dysarthria, dysphagia, supranuclear gaze palsy

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19
Q

amylase is test for

A

pancreatitis

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20
Q

William syndrome is deletion on which chromosome

A

7

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21
Q

is Marfan’s associated with mental retardation or autism, both, or neither?

A

Neither

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22
Q

what bleed causes brief loss of consciousness, followed by lucid period and then further deterioration

A

epidural hematoma

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23
Q

which artery torn in epidural hematoma

A

middle meningeal artery

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24
Q

Bupropion is an ______ (inhibitor or inducer) of ______ and a substrate of ______

A

inhibitor of CYP 2D6

substrate of 2B6

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25
how do men and women metabolize alcohol differently?
women have less alcohol dehydrogenase in their gut so men metabolize more and women absorb more
26
"worst headache of my life" is problem where and from what
subarachnoid hemorrhage - from intracranial aneurysm or AVM of one of arteria that form Circle of Willis
27
1st neuropsychiatric symptom of Huntington's is usually
depression
28
can you have bradykinesia in Huntington's?
yes
29
what can be precipitated by chiropractic adjustments?
vertebral artery dissections
30
FDA treatment for postherpetic neuralgia
gabapentin
31
carbon monoxide poisoning affects which brain areas
cerebral cortex, hippocampus, cerebellar cortex, basal ganglia
32
Stiff person syndrome
persistent limb rigidity and spasms from autoantibodies against glutamic acid decarboxylase
33
cataplexy vs catalepsy
cataplexy - loss of muscle tone with strong emotions (narcolepsy) catalepsy - posturing (catatonia)
34
mirtazapine MOA
5HT3 and alpha2 antagonism
35
what personality trait increases risk of cardiac disease in men
hostility
36
Prader Willi triad
hyperphagia, hypomentia, hypogonadism
37
Angleman's syndrome
severe intellectual disability, microcephalous, laughter, seizures. rigidity, jerky movements
38
what is this - rapidly progressing dementia, exaggerated startle response, myoclonus
CJD
39
what is most common complication of pseudotumor cerebri
visual impairment from papilledema
40
does men's sexual desire change as they get older?
no
41
infantile secure attachment associated with what outcome
emotional and social competence
42
Kohut's "bipolar self" composed of 2 systems of narcissistic perfection which are...
1) system of ambitions - the narcissistic self 2) system of ideals - idealized parental imago
43
brain areas for episodic memory
medial temporal lobe anterior thalamic nuclei mammillary bodies fornix prefrontal cortex
44
what does episodic memory remember
explicit, declarative awareness - eg. what you ate for a meal earlier that day, where you went on last vacation
45
brain areas of semantic memory
inferolateral temporal lobes
46
brain areas of procedural memory
basal ganglia, cerebellum, supplementary motor area
47
Area for TMS for depression
left dorsolateral prefrontal cortex
48
NeuroStar TMS can be indicated after youve failed how many trials of antidepressants?
one
49
how do atypical antipsychotics produce less EPS compared to first gen?
rapid dissociation from D2 receptors - low affinities and bind loosely and rapidly released
50
conversion disorder rates highest among which populations?
rural population little education low intelligence low SES military peeps with combat history
51
MDMA MOA
block reuptake of serotonin induce massive release of serotonin from neurons
52
what damage does MDMA cause
damage to serotonergic nerve terminals decreases in serotonin transporter binding
53
Minnesota Multiphasic Personality Inventory (MMPI) has three validity scales which are...
lie scale (L) infrequency scale (F) suppressor scale (K)
54
infrequency scale of MMPI useful at identifying
malingering, illiteracy, confusion, psychosis, panic
55
lie scale of MMPI useful at identifying
test if patient is being honest in answering questions
56
suppressor scale of MMPI useful at doing what
decreasing false positives and false negatives
57
T3 (triiodothyronine) should not be taken in which patients
patients with cardiac dz/acute MI/angina/HTN thyrotoxicosis adrenal insufficiency
58
T3 (triiodothyronine) drug interactions to watch out for
potentiate effects of warfarin decrease insulin decrease digitalis watch thyroid levels if coadministered with SSRIs, TCAs, lithium, carbamazepine
59
does eszopiclone lead to dependence?
no
60
side effects of eszopiclone
hallucinations, sleep walking
61
how long after patient stopped drinking does GGT return to normal?
8 weeks
62
primary vs secondary vs tertiary causes of adrenal insufficiency areas
primary - adrenals secondary - pituitary tertiary - hypothalamus
63
psychiatric symptoms of adrenal insufficiency
depression, apathy, irritability, psychosis, delirium
64
what happens to concentrations of depakote and lamotrigine when taken together?
lamotrigine levels increase depakote levels decrease
65
what happens to concentrations of carbamazepine and lamotrigine when taken together?
lamotrigine levels decrease
66
what happens to concentrations of carbamazepine and depakote when taken together?
carbamazepine levels increase
67
cerebellum forms at what age
1 year
68
myelnation of peripheral nerves completes at what age
2 years
69
fine pincer grasp develops around
9-12 months
70
ability to sit without support occurs at
6 months
71
clonazepam is slowly or rapidly absorbed?
rapidly
72
diazepam is slowly or rapidly absorbed?
rapidly
73
sex differences in rates of OCD?
equal among men and women
74
how long should IV/IM thiamine + dextrose be given in alcohol withdrawal?
3 days
75
elderly person on carbamazepine gets delirious. what happened?
hyponatremia from vasopressin effect
76
most antipsychotics metabolized through the liver except which one?
paliperidone
77
what type of validity is this - diagnosis based on general consensus among experienced clinicians?
face validity
78
what type of validity is this - diagnosis based on characteristic features that distinguish it from other disorders
descriptive validity
79
what type of validity is this - diagnosis will allow clinicians to accurately predict treatment response and clinical course
predictive validity
80
what type of validity is this - diagnosis based on an understanding of the underlying validity
construct validity
81
desvenlafaxine renally or hepatically excreted?
renally
82
Does desvenlafaxine also cause HTN like venlafaxine?
yes
83
blood levels of lithium at each level of toxicity (mild/moderate/severe)
mild: 1.5-2 mEq/L moderate: 2-2.5 severe: >2.5
84
atomoxetine takes up to how many weeks to feel full effect?
10 weeks
85
Does duloxetine cause HTN like venlafaxine?
no
86
can patients on MAOIs consume vodka?
yes - small amounts of clear alcohol but no rap beer, red wine, some white wines, and sherry
87
can patients on MAOIs consume smoked fish and caviar?
no
88
which drug of abuse causes perioral rash?
inhalants
89
REM latency increased or decreased in narcolepsy?
decreased
90
is risk of agranulocytosis in clozapine users dose related?
no
91
is risk of seizures in clozapine users dose related?
yes
92
are schizophrenic patients more likely to commit homicide?
no
93
most common form of dementia
Alzheimer's (50-60% of dementias)
94
prevalence of Alzheimer's in patients over 85
20-40%
95
does mirtazapine block serotonin or NE reuptake?
no

Psych Boards 2023 (8 decks)

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