Pentose phosphate pathway Flashcards
1
Q
What are the products of the pentose phosphate pathway?
A
Ribose-5-phosphate and NADPH
2
Q
For what is NADPH used?
A
Lipid biosynthesis
3
Q
What is the rate-limiting enzyme in the PPP?
A
Glucose-6-phosphate dehydrogenase
4
Q
In what type of population is hemolytic anemia from deficiency in G6PDH prevalent?
A
Mediterranean and black populations
5
Q
What causes hemolytic anemia in G6PDH deficiency?
A
A lack of NADPH, which is needed to reduce glutathione, which itself is an important in reduction of various proteins
6
Q
Wernicke-Korsakoff syndrome
A
Most commonly due to a thiamine deficiency, resulting in a transketolase deficiency
