Promethazine

Question 1

Trade name

Answer 1

Phenergan

Question 2

Class

Answer 2

Phenothiazine, anti-emetic, anti-histamine

Question 3

Mechanism of action

Answer 3

Acts on blood vessels, Gi, respiratory system by competing with histamine for HI receptor site; blocks action of histamine; possesses sedative properties, anti-cholinergic, and anti-emetic activity, potentiates the narcotic effect

Question 4

Indications

Answer 4

Nausea, vomiting, motion sickness, sedation, potentiation of analgesic effects of narcotics

Question 5

Contraindications

Answer 5

Hypotension in volume deleted pts. Do not use in pots that have anticholinergic syndromes, children , than 3 yrs of age, hypersensitivity to phenothiazines phlebitis, pregnancy

Question 6

Adverse effects

Answer 6

EPS, drowsiness, hypotension, palpitations

Question 7

Routs of admin

Answer 7

IV/IO - must be diluted or IM if no IV

Question 8

Onset of action

Answer 8

Onset 3-5 min peak at 30-60 min duration 4-6hrs

Question 9

Adult dose

Answer 9

6.25 - 25mg IV/IO

Question 10

Pediatric dose

Answer 10

Not

Question 11

Protocols used

Answer 11

A-17: Nausea and Vomiting

B-3: Pediatric Nausea and Vomiting