CNS Flashcards
1
Q
GABA
A
- Inhibitory NT
RECEPTORS: GABA-A/B
2
Q
Glycine
A
- Inhibitory NT
- Local Interneurons in the spinal chord and brain stem
- *Stricknine and Tetanus inhibit Glycine**
3
Q
Glutamate
A
- Excitatory NT
- Ionatropic Receptors
- Metabotropic Receptors - I, II, III (II and III are presynaptic Autoreceptors)
EXCITOXICITY: Neuronal death from LOTS of Glutamate
4
Q
Ionatropic Receptors: KA
A
Kainate
- Hippocampus, Cerebellum, Spinal Cord
- Mediate Fast Depolarization
5
Q
Ionatropic Receptors: AMPA
A
Alpha-Amino-3-Hydroxy-5-methyl-4-isoxazole Proprionic Acid (Just call it AMPA)
- Present on All Neurons
- Mediate Fast Depolarization
6
Q
Ionatropic Receptors: NMDA
A
N-Methyl-D-Aspartate
- All neurons in the CNS
- Long Term Potentiation (LTP)
- Prolonged (hours to days) INC in the size of a postsynaptic response to a presynaptic response to a presynaptic stimulus of a given strength
7
Q
Ach
A
- Spinal Cord - RENSHAW CELLS
- Neurons in the neostriatum, medial septal nucleus, reticular formation
- M1: Slow excitation
- M2: Slow Inhibition
- Nm
8
Q
Dopamine
A
- Substantia Nigra –> Neostriatum
- Ventral Tegmental Region –> Limbic Cortex
D1-D5
9
Q
Norepi
A
Hypothalamus, limbic system, reticular formation
A1B - Enhances Excitatory inputs by both indirect and direct mechs
-Attention and Arousal
A2 - INHIBITORY
10
Q
5HT
A
- Neurons in the Raphe or midline regions of the pons and upper brain stem
- 5HT1-4 (5HT3 is IONOTROPIC)
11
Q
Peptides
A
Enkephalins
Endorphins
Neurotensin
Substance P
12
Q
Actions of CNS Drugs
A
- CNS Depressants
- CNS Stimulants
Drugs that Selectively modify CNS Fxn: Anticonvulsants, Anti-Parkinson’s Agents, Opioid Analgesics, Anti-Depressants, Antimanic and Antipsychotics Agents
13
Q
CNS Stimulants: ADHD
A
Amphetamine & Dexoamphetamine (Adderall)
Methamphetamine (Desoxyn)
Methyphenidate (Ritalin)
14
Q
CNS Stimulants: Narcolepsy, Shift Work Sleep Disorder (SWSD)
A
Modafinil (provigil)
15
Q
CNS Stimulants: Local Anesthetics
A
Cocaine
