DERM - Injury, allergy, atopy Flashcards
Final strength for remodeling / maturation of a would takes how long?
12 weeks
definition: atopic dermatitis
chronic, pruritic, inflammatory skin disease with a wide range of severity
what differentiates atopic dermatitis from psoriasis?
- atopic dermatitis: flexural surfaces
- psoriasis: extensor surfaces
what is the atopic triad?
- asthma
- atopic dermatitis
- allergic rhinitis
what is samter’s triad?
- aspirin
- asthma
- atopy
what are the 4 main components of atopic dermatitis treatment?
- anti inflammatory
- antibacterial
- moisturizer
- anti-pruritic
what links atopy to asthma?
filaggrin
what is the cardinal symptoms of urticaria?
itch
how does angioedema differ from urticaria?
angioedema can be caused by the same pathogenic mechanisms as urticaria, but the pathology is in the deep dermis and subcutaneous tissue and swelling is the major manifestation
what is the major effector cell in urticaria?
mast cell
what is immunologic (IgE dependent) urticaria?
- antigen binds to IgE on mast cell surface causing degranulation, which results in release of histamine
- histamine binds to H1 and H2 receptors to cause arteriolar dilation, venous constriction and increased capillary permeability
what is non-immunologic (IgE independent) urticaria?
- not dependent on binding of IgE receptors
- e.g. aspirin, physical stimuli, dermagraphism, NSAIDs, morphine (direct histamine releaser)
does samter’s triad cause IgE dependent or independent urticaria?
independent
what is the first line treatment for acute and chronic urticaria?
oral H1 antihistamines (1st generation LESS well tolerated)
what is the first line therapy for anaphylaxis?
- EPI
- IV fluids
- oxygen
