R/O - Introduction to arthritis

Question 1

pubic symphysis, SI, and spine are what type of joints?

Answer 1

amphiarthroses

Question 2

what are the red flag for joint exam?

Answer 2

• acute monoarticular arthritis with inflammation
• cranial symptoms in elderly patients with muscle pain
• morning stiffness lasting over an hour in patients with back pain

Question 3

what are the 3 reasons for lab testing in arthritis workup?

Answer 3

• screening
• confirming a diagnosis
• monitoring treatment

Question 4

what do acute phase reactants monitor?

Answer 4

intensity of inflammation

Question 5

which changes faster - ESR or CRP?

Answer 5

CRP

Question 6

rheumatoid factor is an antibody to the ____ portion of immunoglobulin ____

Answer 6

• Fc

- IgG

Question 7

do RF levels correlate with disease activity?

Answer 7

NO

Question 8

anti-CCP antibodies are useful in what situation?

Answer 8

RF-negative patients with RA

Question 9

can CCP antibodies be used as a screening test?

Answer 9

NO

Question 10

what is the screening test of choice for autoimmune rheumatic disease?

Answer 10

ANA antibodies

Question 11

a centromere pattern of ANA antibodies suggests what condition?

Answer 11

CREST

Question 12

nucleolar pattern of ANA antibodies suggests what condition?

Answer 12

systemic scleroderma

Question 13

anti double stranded DNA antibodies are specific to what condition?

Answer 13

SLE

Question 14

anti-Jo1 antibodies are specific to ___________

Answer 14

polymyositis

Question 15

anti-centromere antibodies are specific to __________

Answer 15

limited scleroderma - CREST

Question 16

anti-U1 RNP antibodies are specific to _____________

Answer 16

primarily MCTD

Question 17

do antinuclear antibodies correlate with disease activity?

Answer 17

no

Question 18

what analysis is mandatory for acute monoarthritis?

Answer 18

synovial fluid analysis