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M2015/16 > Hemonc 412,413 > Flashcards

Hemonc 412,413 Flashcards

1
Q

What are the 2 most commonly used glucocorticoids in cancer chemotherapy?

A

Prednisone, prednisolone

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2
Q

Diabetic retinopathy is treated with what Monoclonal antibody?

A

Bevacizumab -> anti- VEGF

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3
Q

Tx of Adenocarcinoma of the lung and MOA?

A

Erlotinib: EGFR tyrosine kinase inhibitor

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4
Q

Rituximab inhibits which CD?

A

CD20

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5
Q

Pt that has been treated with BCR-ABL mutation presents with edema, what was the Tx?

A

Imatinib - Fluid retention.

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6
Q

What drug would you use to treat a 68 year old female with breast ca?

A

Raloxifene, useful to prevent osteoporosis.

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7
Q

HER-2 (c-erbB2) is what kind of receptor?

A

tyrosine kinase receptor

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8
Q

Which Tx blocks the binding of estrogen to ER ⊕ cells?

A

(SERMs)—receptor antagonists in breast

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9
Q

Tx and MOA that treats Metastatic melanoma?

A

Vemurafenib

Small molecule inhibitor of BRAF oncogene ⊕ melanoma

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10
Q

Which anti-inflam drugs can cause cataracts, acne, hypertension, peptic ulcers and psychosis?

A

Prednisone, prednisolone

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11
Q

Pt undergoing Tx for B-cell neoplastic presents with nonenhancing areas of demyelination on MRI. What was the Tx that caused this?

A

Rituximab due to developement of progressive multifocal leukoencephalopathy

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12
Q

Toxicity of Herceptin?

A

Cardiotoxicity

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13
Q

SE: of EGFR tyrosine kinase inhibitor?

A

rash, photosen.

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14
Q

(SERMs)—receptor antagonists of the breast causes an incr risk of endometrial cancer?

A

Tamoxifen

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15
Q

This drugs SE are similar to a dz that is caused by shistosomiasis?

A

CYclophosphamide–> hemorrhagic cystitis

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16
Q

Pt in chemotherapy acquires hearing loss, what was the Tx?

A

Cisplatin/Carboplatin

17
Q

3 chemo drugs where pts need to be cautious to prevent infections?

A 
myelosuppression cause by: 
5-FU Ž 
6-MP Ž 
Busulfan
Cladribine
Methotrexate

M2015/16 (27 decks)

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