5.2

Question 1

what cells cause insulinoma

Answer 1

beta cells

Question 2

what inherited disease in insulinoma associated with

Answer 2

MEN1

Question 3

what is whipples triad associated with

Answer 3

insulinoma

Question 4

what is whipples triad

Answer 4

episodic hypoglycemia
decreased glucose <40-50
improvement with glucose within 15 min

Question 5

diagnosis of insulinoma

Answer 5

after 72 hour fast
decreased glucose < 45
increased insulin
increased C peptide
increased proinsulin
decreased beta-hydroxybutyrate

Question 6

what cells cause glucagonoma

Answer 6

alpha cells

Question 7

where does glucagonoma commonly metastasize

Answer 7

liver (hepatic mets)

Question 8

5 D’s associated with glucagonoma

Answer 8

decreased weight
DM
diarrhea
depression
dermatitis (necrolytic migratory erythema)

Question 9

what is the most common presenting symptom of patients w glucagonoma

Answer 9

weight loss

Question 10

how to diagnose glucagonoma

Answer 10

> 500 blood glucose

Question 11

what inherited disease in glucagonoma associated with

Answer 11

MEN1

Question 12

what is another characteristic lab finding in glucagonoma

Answer 12

hyperaminoacidemia

Question 13

treatment for glucagonoma

Answer 13

surgery if no mets

there are usually mets – so somatostatin analogs

Question 14

another very important and common symptom in glucagonoma

Answer 14

DVT, PE

Question 15

MEN1

Answer 15

3 P’s

pituitary
parathyroid
pancreas

Question 16

what gene is defected in MEN1

Answer 16

menin gene

Question 17

characteristics of MEN2

Answer 17

medullary thyroid carcinoma
pheochromocytoma
hyperparathyroidism
Hirschsprung

Question 18

characteristics of MEN3

Answer 18

medullary thyroid carcinoma
pheochromocytoma
neuromas
marfanoid habitus

Question 19

what should you do for MEN2

Answer 19

prophylactic thyroidectomy

Question 20

at what osmolality is HHS resolved

Answer 20

< 315 osmolality
able to eat

Question 21

what is the MC cause of ESRD in US

Answer 21

DM

Question 22

what type of vision loss do we see in glaucoma

Answer 22

peripheral vision loss

Question 23

is open angle glaucoma painful or painless

Answer 23

painless

Question 24

what will you see on PE for acquired cataracts

Answer 24

absent red reflex
opaque lens

Question 25

fasting plasma glucose and hospitalized patients

Answer 25

fasting plasma glucose should not be used to diagnose DM in hospitalized patients

Question 26

what is characteristic of symmetric polyneuropathy / diabetic neuropathy

Answer 26

stocking glove pattern

Question 27

goal for preprandial glucose levels

Answer 27

70-130

Question 28

goal for peak postprandial glucose levels

Answer 28

< 180

Question 29

what do you need to check within one month of starting ACE/ARB

Answer 29

BUN/creatinine

Question 30

fasting plasma glucose level to diagnose DM

Answer 30

> /= 126

Question 31

fasting plasma glucose level for prediabets

Answer 31

100-125

Question 32

fasting plasma glucose level for normal

Answer 32

< 100

Question 33

glucose level to diagnose DM for oral glucose tolerance test

Answer 33

> /= 200

Question 34

glucose level for prediabetes for oral glucose tolerance test

Answer 34

140-199

Question 35

normal glucose level for oral glucose tolerance test

Answer 35

< 140

Question 36

A1C to diagnose DM

Answer 36

> /= 6.5

Question 37

A1C for prediabetes

Answer 37

5.7-6.4

Question 38

A1C for normal

Answer 38

< 5.7