Actinobacillus

Question 1

Actinobacillus pleuopneumoniae

• general
• biotypes

Answer 1

1. Very important disease in swine rearing

Younger pigs,

Question 2

Actinobacillus pleuropneumoniae

- Pathogenesis

Answer 2

Inhalation, Tonsils/nose -> Terminal bronchioli, alveoli

Question 3

Actinobacillus pleuropneumoniae

- Virulence Factors

Answer 3

Adhesion: fimbriae
Replication: Fe necessary - transferrin binding proteins, hemoglobin binding proteins
Exotoxin production: Apx toxins
Heat shock proteins
OMPs
Enzymes: proteases, Cu-Zn-SOD

Question 4

Actinobacillus pleuropneumoniae

-symptoms

Answer 4

Respiratory distress
Hyperacute and Acute - fibrinous pleuritis and hemorrhagic necrotizing pneumonia (blood coming out of nose); dead within a couple hours

Question 5

Actinobacillus suis

Answer 5

Lesions similar to APP but less extensive
Carriers - tonsils and vagina
Not host specific - pathogenic for mice

Question 6

Actinobacillus equuli

Answer 6

Foal:
“Sleep foal disease”
Septicemia

Adult:
Abortions or birth of “sleepy foal disease” foal
Frequently localization in joints

Question 7

Actinobacillus lignieresii

Answer 7

Wooden tongue
Inhabitant of nasopharynx
Lesions - capsule of connective tissue with multiple granuloma’s containing yellowish pus and “sulfur granules”