5.3 - Normal Microbiota Flashcards Preview

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Flashcards in 5.3 - Normal Microbiota Deck (27)
1

Provide the unique role or specific adaptation for Lactobacillus

human niche in the vagina, major protection against vaginosis

2

Provide the unique role or specific adaptation for Candida albicans

human niche in the vagina, budding yeast, overgrowth with oral antibiotics

3

Provide the unique role or specific adaptation for Helicobacter pylori

Human niche in the stomach, makes its environment hospitable by raising the pH

4

Provide the unique role or specific adaptation for Clostridium difficile

Human niche in the colon, 2-10% healthy adults colonized, 20-50% hospitalized adults colonized; forms endospores

5

Provide the unique role or specific adaptation for Escherichia coli

Human niche in the colon, member of the Enterobacteriaceae; synthesizes vitamin K

6

Provide the unique role or specific adaptation for Bacteroides

Human niche in the colon, dominant genus in this site; growth stimulated by bile

7

Provide the unique role or specific adaptation for Propionibacterium acnes

Human niche in the hair follicles, sebaceous glands, produces propionic acid which contributes to stinky feet

8

Provide the unique role or specific adaptation for Staphylococcus epidermidis

Human niche in the skin, hardy, relatively resistant to desiccation, salt and acid

9

Provide the unique role or specific adaptation for streptococcus pneumoniae

human niche in the nasopharynx, 5-40% population colonized at this site; known for its capsule

10

Provide the unique role or specific adaptation for staphylococcus aureus

Human niche in the nose, ~30% population colonized at this site; hardy, relatively resistant to desiccation, salt, acid; produces many toxins

11

Provide the unique role or specific adaptation for Streptococcus mutans

Human niche is in the mouth, produces acid that demineralize enamel

12

What is normal microbiota

microorganisms frequently found on or in the body of healthy people

13

Commensalism

one member benefits while the other is relatively unaffected

14

Mutualism

both members benefit

15

Resident microbiota

is a type of colonization. Relatively fixed, washing, sweating doesn't significantly alter, if disturbed, reestablishes

16

Transient microbiota

type of colonization, from the environment, food and water, can be either non or pathogenic

17

Pathogen

always associated with disease

18

Opportunist

don't produce disease in their normal environment, but can cause disease when introduced into unprotected sites, or when overgrow their normal environment

19

Colonization

if the bacteria, fungi... are growing but there is no pathology associated with it

20

Infection

if the bacteria, fungi... are growing but there is pathology associated with it

21

What are normally sterile sites?

Amniotic fluid, blood, CSF, synovial fluid, deep tissues, organs, brain, sinuses, middle and inner ear, and internal eye.

If microbes are present it is usually diagnostically significant.

22

What sites are normally sterile but can have transients?

Larynx, trachea, esophagus, bronchioles, lower airways.

23

What are sites that are not sterile?

Hair follicles, stomach, upper respiratory tract, mouth, nose, pharynx, perineum, vagina, colon, and skin.

24

What are the roles of normal microbiota?

-Participate in end stages of food digestion
-Provide some vitamins
-Help protect against pathogens
-Contribute to maturation of immune system
-Stimulate immune response
-Competition for binding sites, space
-Relatively constant unless exogenous factors like acid neutralization antibiotic treatment, which will disrupt balance.

25

What is Dysbiosis?

Refers to microbial imbalance on or inside the body.

26

What is CDAD?

Clostridium difficile-associated diarrhea

27

How is CDAD a dysbiosis?

Antibiotic treatment kills normal flora and allows C. diff to bind and multiple as many strains are antibiotic resistant, they release toxin and cause diarrhea