Flashcards in 6.12 Intro to ANS Pharmacology Deck (20)
What are drug targets of the ANS?
1) Muscarinic Receptors
2) Nicontinic receptors
3) AcH Inhibitors
4) Adrenergic Receptors (block and stimulate)
Discuss Acetylcholinesterase inhibitors
-An indirect drug effect (drug target in the PSNS)
-The primary mechanism that limits the synaptic concentration and duration of acetylcholine is its inactivation by acetylcholinesterase.
Discuss Beta-1 adrenergic Receptor
Heart increase rate (chronotropic), increase force of contraction (isotropic); increase nerve conduction
Discuss Beta-2 adrenergic Receptor
-Blood vessels dilate
Discuss Beta-3 adrenergic Receptors
Discuss Alpha-1 adrenergic Receptors
Blood vessels vasoconstriction
Discuss Alpha-2 adrenergic Receptor
-Presynaptic nerve terminal (autoregulate)
-Decrease NE release
-In CNS causes a decrease SNS tone; analgesia
Discuss Beta Blockers
-Primary therapeutic goal is to block beta-1-receptors with minimal effect.
-Beta-2-receptors: bronchoconstriction and vasoconstiction.
Discuss Alpha Blockers
Block alpha-1-receptors with minimal effect on alpha-2-receptors
What two enzymes can effect norepinephrine?
MAO: Monoamine oxidase
What are postsynaptic neural synapse drug targets?
-Muscarinic ACH receptors
What are example of direct stimulate or blocked post synaptic receptors?
1) Muscarinic receptor stimulant- bronchocostriction or bronchospasm
2) Muscarinic receptor blocker: bronchodilation
What are indirect effects of drugs?
1) stimulate the release of neurotransmitter from pre-synaptic neuron
2) Inhibit systems that limit the synaptic concentration duration of neurotransmitters.
3) Inhibit the release of neurotransmitter from pre-synaptic neuron.
What are symptoms of stimulation of muscarinic receptors?
-Diarrhea, Urination, miosis, baradycardia, brochoconstriction, emesis, lacrimation, salivation, and sweating.
What are symptoms of Anticholinergic drug excess?
1) Confusion, memory loss
2) Blurred Vision
4) Urinary retention, enlarged prostate.
5) Dry mouth
What is semi-selectivity?
-Albuterol is semi-selective beta-2-receptor agonist used as a bronchodilater.
-As its dose is increased it tends to increase heart rat via beta-1-receptor stimulation
-Travels to multiple locaton over the whole body and binds all over.
What are stimulation of the sympathetic nervous system?
1) Adrenergic agents
What are inhibition of the sympathetic nervous system?
What are stimulates of the parasympathetic nervous system?
2) Cholinergic agonists
6) Acetylcholinesterase inhibitor (indirect stimulation)