6.12 Intro to ANS Pharmacology Flashcards Preview

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Flashcards in 6.12 Intro to ANS Pharmacology Deck (20)
1

What are drug targets of the ANS?

1) Muscarinic Receptors
2) Nicontinic receptors
3) AcH Inhibitors
4) Adrenergic Receptors (block and stimulate)

2

Discuss Acetylcholinesterase inhibitors

-An indirect drug effect (drug target in the PSNS)
-The primary mechanism that limits the synaptic concentration and duration of acetylcholine is its inactivation by acetylcholinesterase.

3

Discuss Beta-1 adrenergic Receptor

Heart increase rate (chronotropic), increase force of contraction (isotropic); increase nerve conduction

4

Discuss Beta-2 adrenergic Receptor

-Lungs bronchodilate
-Uterus relax
-Blood vessels dilate

5

Discuss Beta-3 adrenergic Receptors

Bladder relax

6

Discuss Alpha-1 adrenergic Receptors

Blood vessels vasoconstriction

7

Discuss Alpha-2 adrenergic Receptor

-Presynaptic nerve terminal (autoregulate)
-Decrease NE release
-In CNS causes a decrease SNS tone; analgesia

8

Discuss Beta Blockers

-Primary therapeutic goal is to block beta-1-receptors with minimal effect.
-Beta-2-receptors: bronchoconstriction and vasoconstiction.

9

Discuss Alpha Blockers

Block alpha-1-receptors with minimal effect on alpha-2-receptors

10

What two enzymes can effect norepinephrine?

MAO: Monoamine oxidase
COMT

11

What are postsynaptic neural synapse drug targets?

-AChE inhibitors
-Muscarinic ACH receptors

12

What are example of direct stimulate or blocked post synaptic receptors?

1) Muscarinic receptor stimulant- bronchocostriction or bronchospasm
2) Muscarinic receptor blocker: bronchodilation

13

What are indirect effects of drugs?

1) stimulate the release of neurotransmitter from pre-synaptic neuron
2) Inhibit systems that limit the synaptic concentration duration of neurotransmitters.
3) Inhibit the release of neurotransmitter from pre-synaptic neuron.

14

What are symptoms of stimulation of muscarinic receptors?

-Diarrhea, Urination, miosis, baradycardia, brochoconstriction, emesis, lacrimation, salivation, and sweating.

15

What are symptoms of Anticholinergic drug excess?

1) Confusion, memory loss
2) Blurred Vision
3) Constipation
4) Urinary retention, enlarged prostate.
5) Dry mouth

16

What is semi-selectivity?

-Albuterol is semi-selective beta-2-receptor agonist used as a bronchodilater.
-As its dose is increased it tends to increase heart rat via beta-1-receptor stimulation
-Travels to multiple locaton over the whole body and binds all over.

17

What are stimulation of the sympathetic nervous system?

1) Adrenergic agents
2) Agonists
3) Sympatomimetics
4) Catecholamines

18

What are inhibition of the sympathetic nervous system?

1) Antiadrenergic
2) Blockers
3) Antagonists
4) Sympatholytics

19

What are stimulates of the parasympathetic nervous system?

1) Cholinergics
2) Cholinergic agonists
3) Parasympathomimetics
4) Muscarinic
5) Nicotinic
6) Acetylcholinesterase inhibitor (indirect stimulation)

20

What are inhibitors of the parasympathetic nervous system?

1) Anticholinergics
2) Blockers
3) Parasympatholytics
4) Antimuscarinic