Macrophages

Question 1

Lung macrophage

Answer 1

alveolar macrophage

Question 2

What do M1 macrophages produce

Answer 2

IL-1, Il-12, Il-23

Question 3

What are the minority monocytes?

Answer 3

Patrolling. They roll around blood vessels surveying for damage. They express FcyRIII.

Question 4

How do macrophages interact with T cells?

Answer 4

Through their CD40 receptor. T cells have the receptor (CD40L).

Question 5

What stimulates the growth of new monocytes in the bone marrow?

Answer 5

IL-3 and GM-CSF.

Question 6

brain macrophage

Answer 6

microglial cells

Question 7

What factor recruits monocytes from the blood?

Answer 7

CCL2 induced by TH1 T cell signaling (Producted of TNFa) binds to CCR2 on the monocyte. They will follow the gradient from bone marrow to the site of infection

Question 8

What are the factors that make M2 macrophages?

Answer 8

IL-4 and IL-13

Question 9

What do M2 macrophages produce?

Answer 9

IL-10 and TGF-b

Question 10

What are the majority of monocytes and what is its marker?

Answer 10

Classical monocytes. They express CD14 and flow freely in blood

Question 11

liver macrophage

Answer 11

kuppfer cells

Question 12

What are the factors that make M1 macrophages?

Answer 12

TLR signaling, IFN-gamma