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Pharmacology > Cholinergic Pharmacology > Flashcards

Cholinergic Pharmacology Flashcards

1
Q

Antidote for atropine overdose (anticholinergic toxicity)

A

Physostigmine

*“phyxes” atropine overdose

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2
Q

How does pralidoxime (2-PAM) work? Use.

A

Pull off the phosphate from the AchE (before aging)

Organophosphate (parathion) insecticides intoxication ▶️ AchE inhibitors

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3
Q

How does the organophosphate inhibit the AchE?

A

Phosphorylation of AchE

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4
Q

How is M3 receptor stimulated in blood vessels? What is the response?

A
  • drugs, endogenously is not activated ▶️ is not innervated

- vasodilation ▶️ ⬇️ blood pressure, reflex tachycardia

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5
Q

Muscarinic agonist used to diagnose asthma

A

Methacholine

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6
Q

Unique symptom or sign of the cholinergic syndrome by organophosphates that can not be treated by atropine? How do you treat it?

A

Muscle paralysis

PAM-2 (pralidoxime)

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Pharmacology (22 decks)

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