Drugs For Inflammatory and Related Disorders

Question 1

Most important side effects of cimetidine

Answer 1

Major inhibitor of cytochrome P450 ▶️ ⬆️ effects of some drugs
⬇️ androgens ▶️ gynecomastia, ⬇️ libido

Question 2

Analog of which prostaglandin maintains ductus arteriosus?

Answer 2

PGE1 - alprostadil

Question 3

Risk if take ASA during viral illness

Answer 3

Reye syndrome

Question 4

Important symptoms and signs of salicylism. Importance.

Answer 4

Tinnitus, vertigo, deafness

First signs of toxicity

Question 5

Which NSAID doesn’t have impacts on renal function? Why?

Answer 5

Sulindac ▶️ not ⬇️ PGI2, PGE2 ▶️ maintain GFR, RBF (dilate renal vasculature)
Rest of NSAID block them

Question 6

Selective COX2 inhibitor present cross-hypersensitivity with which drugs?

Answer 6

Sulfonamides

Question 7

What is the Recombinant form of TNF receptor? Uses and side effects.

Answer 7

Etanercept ▶️ bind to TNF
Rheumatoid arthritis
Infections

Question 8

Infliximab and adalimumab what do they have in common? side effects.

Answer 8

Monoclonal antibody to TNF

Infections

Question 9

Mechanism of action of anakinra.

Answer 9

IL-1 receptor antagonist

Question 10

Allopurinol and febuxostat can block metabolism of which other drugs?

Answer 10

6-Mercaptopurine

Azatioprine

Question 11

Mechanism of action and uses of rasburicase.

Answer 11

Recombinant urate oxidase ▶️ ⬇️ Uric acid level ▶️ prevent tumor lysis syndrome before chemotherapy
Give if Uric acid level high before start chemotherapy