Acid Base Regulation - Colombo Flashcards

1
Q

Acid donating a proton and base accepting a proton is which definition?

A

Bronsted-Lowry

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2
Q

What are the two categories of acid in blood?

A

Volatile (carbonic acid)

Non volatile

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3
Q

High concentration of H+ is called?

A

Acidemia (acidosis is blanket term for things leading to acidemia)

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4
Q

Low Concentration of H+ is called?

A

Alkalemia (alkalosis is blanket term for things leading to alkalemia)

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5
Q

What are the three pH regulatory systems of the body?

A

Lungs-remove CO2
Kidneys- remove H+,retain HCO3
Buffering-resist pH change

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6
Q

What are three key buffer systems?

A

Bicarbonate-extra cellular
Phosphate-intracellular
Proteins

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7
Q

Strong acids have a high or low pKa?

A

Low

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8
Q

pH=pKa + log [A-]/[HA] is what equation?

A

Henderson-hasselbalch

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9
Q

Hypo-ventilation results in?

A

Respiratory acidosis

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10
Q

Hyperventilation results in?

A

Respiratory alkalosis

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11
Q

Abnormal loss of HCO3 results in?

A

Metabolic acidosis

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12
Q

Abnormal retention of HCO3 results in?

A

Metabolic alkalosis

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13
Q

Physiological pH is typically what?

A

7.4

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14
Q

What is the Volatile Acid in the human body?

A

Carbonic Acid

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15
Q

What does pH actually tell you?

A

the ratio between conjugate base/acid in the blood and thus how much H+ is present

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16
Q

does buffering remove H+ ions?

A

no it mere “absorbs them”

17
Q

What kind of acid can the lungs deal with?

A

only volatile acid (carbonic acid)

18
Q

What is the primary buffering molecule in the Extracellular fluid (ECF)?

A

Bicarbonate

19
Q

What is the primary buffering molecule in the intracellular fluid (ICF) and tubules of the kidney?

A

Phosphate

20
Q

Why is phosphate used in the ICF instead of Bicarbonate?

A

because the pH intracellularly is near the pKa of the phosphate buffer system so it is at peak efficiency

21
Q

If a patient has a pH of less than 7.4 and an HCO3- concentration of less than 24mM/L they have what acid base disorder?

A

Metabolic Acidemia

22
Q

If a patient has a pH of more than 7.4 and an HCO3- concentration greater than 24mM/L they have what acid base disorder?

A

Metabolic Alkalemia

23
Q

If a patient has a pH of less than 7.4 and an PCO2 concentration greater than 40mmHg they have what acid base disorder?

A

Respiratory Acidemia

24
Q

If a patient has a pH of more than 7.4 and an PCO2 concentration less than 40mmHg they have what acid base disorder?

A

Respiratory Alkalemia