laboratory testing in rheumatic diseases Johnston

Question 1

rim pattern

Answer 1

anti DS DNA

Question 2

arthritis- bowel

Answer 2

IBD
UC
crohn’s more seen in this
behcets: ulcers in genital area, oral cavity, associated with arth too

reactive arth
-bowel infection

Question 3

uric acid hyperuricemia

Answer 3

uric acid over 6.8
acute onset often 1st MTP
joints are hot, swollen, tedner, dusky, red
tophi in skin

Question 4

arthritis endocrine

Answer 4

diabetes
-charcot joints, bony desruction of jt that cant feel pain bc of nerve damage

cheiroarthropathy- thick skin and stiff extreemity

thyroid- carpal/tarsal tunel syndrome
hyper PTH
acromegally

Question 5

enthesopathy

Answer 5

inflammation of ligaments and tendons as insert into bony attachment, reactive arth

Question 6

drugs that can cause lupus

Answer 6

SHIPP

sulfanomides
hydralazine
isoniazid
phenytoin
procainamide

Question 7

CT is best for

Answer 7

bony abnormalities, erosions, fractures, degen or inflamm arthritis

Question 8

pitting nails seen in

Answer 8

psoriatic arthritis

Question 9

joint fluid analysis aspiration

normal fluid
non inflammatory
inflammatory

Answer 9

normal under 200

non inflam
200-2000

inflammatory states
2-50K
>50k is septic

Question 10

boutonniere deform

Answer 10

RA

hyperflex of PIP

Question 11

criteria for SLE

Answer 11

malar rash
discoid rash
photosensitivity
oral ulcers
arthritis
serositis
renal
neurologic
hematologic

Question 12

arthritis seen in syndromes involving what organs

Answer 12

skin
bowel
lung
endocrine
eyes

Question 13

Positive RF value >___ by ELISA or > ____ by latex fixation

Answer 13

45 for elisa

1:80 for latex fixation

Question 14

oligo arthritis

Answer 14

3 or less joints involved

Question 15

arthritis- pulmonary

Answer 15

hypertrophic pulmonary oesteoarthritis-- clubing
nodules
effusion
hilar nodes
infiltrates

Question 16

anticentromere antibody in

Answer 16

scleroderma

CREST and progressive systemic sclerosis

Question 17

RF found in what diseases rather than RA

Answer 17

sjogren
cryoglobulinemia
primary biliary cirrhosis
MCT
endocarditis
sLE
sarcoid, malignancy

Question 18

chronic management gouty arthritis

Answer 18

xanthine oxidase inhitor

probenecid

Question 19

MRI

Answer 19

useful for soft tissue abnormalties
-spine, SI, synovitis, tenosynovitis, erosions

IV gadolinium can cause nephrogenic systemic fibrosis in pts with kidney disease

Question 20

pauci arthritis

Answer 20

5 or more involved

Question 21

which imaging for RA

Answer 21

digital radiography

ultrasound for joint

Question 22

ASO and anti DNAse B titers

Answer 22

evidence of preceding group A strep
acute RF
strep may cause arthritis
JONES criteria

Question 23

poly arth

Answer 23

more than 6

Question 24

treatment for acute gouty arthritis

Answer 24

NSAIDS
colchicine
steroids

Question 25

heamtologic finding in SLE

Answer 25

hemolytic anemia with reiculocytosis or
leukopenia or
lymphopenia or
thrombocytopenia

Question 26

bouchard and heberdens nodes

Answer 26

OA

Question 27

arthritis- ophthalmologic

Answer 27

conjnctivitis ins SNSA
iritis
lacrimal enlargement
exerophthalmia
retinopathy

Question 28

homogenous pattern of immunofluorescence

Answer 28

drug induced lupus

Question 29

cytoid bodies

Answer 29

small white lesions on retina in lupus

also get vasulitis (petechiae of retina in lupus)

Question 30

what is sensitive for soft tissue abnormalties, synovitis, tendonitis, bursitis, and soft tissue swelling

Answer 30

US

Question 31

downside to plane radiogrpahs in rheumatic diseases

Answer 31

may not detect early arthritic disease

Question 32

SLE antibody

Answer 32

ANA

anti AM antibodies

Question 33

RF

Answer 33

IgM antibody towards the Fc portion of the IgG antibody

Question 34

speckled anti SSA/B in ___

Answer 34

sjogren

Question 35

swan neck deformity

Answer 35

RA

hyperextension of PIP